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AXL and SHC3
Number of citations of the paper that reports this interaction (PMID
8610109
)
17
Data Source:
HPRD
(in vivo)
AXL
SHC3
Gene Name
AXL receptor tyrosine kinase
SHC (Src homology 2 domain containing) transforming protein 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Extracellular Vesicular Exosome
Cellular_component
Cytosol
Plasma Membrane
Molecular Function
Phosphatidylserine Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Myosin Heavy Chain Binding
Phosphatidylinositol 3-kinase Binding
Protein Heterodimerization Activity
Signal Transducer Activity
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Biological Process
Neuron Migration
Natural Killer Cell Differentiation
Positive Regulation Of Cytokine-mediated Signaling Pathway
Blood Vessel Remodeling
Phagocytosis
Inflammatory Response
Signal Transduction
Spermatogenesis
Peptidyl-tyrosine Phosphorylation
Forebrain Cell Migration
Platelet Activation
Organ Regeneration
Cellular Response To Extracellular Stimulus
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Differentiation
Secretion By Cell
Erythrocyte Homeostasis
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Interferon-alpha
Ovulation Cycle
Apoptotic Cell Clearance
Protein Kinase B Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Maturation
Negative Regulation Of Lymphocyte Activation
Positive Regulation Of Protein Kinase B Signaling
Vagina Development
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Dendritic Cell Differentiation
Negative Regulation Of Dendritic Cell Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Central Nervous System Development
Learning Or Memory
Insulin Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Neurotrophin TRK Receptor Signaling Pathway
Pathways
Signaling by VEGF
VEGFA-VEGFR2 Pathway
Signalling to ERKs
Signalling by NGF
Insulin receptor signalling cascade
SHC-mediated signalling
SHC-related events triggered by IGF1R
SHC-related events
NGF signalling via TRKA from the plasma membrane
IGF1R signaling cascade
Signal attenuation
Signalling to RAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
SHC-mediated signalling
Signaling by Insulin receptor
Drugs
Diseases
GWAS
Response to statin therapy (LDL-C) (
22331829
)
Protein-Protein Interactions
21 interactors:
ADAM10
CBL
FBXO25
GAS6
GRB2
IL15RA
IL2RG
LCK
NCK2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
RANBP9
SHC1
SHC3
SOCS1
SRC
TNS2
TYRO3
16 interactors:
ALK
APP
ARHGAP32
AXL
EGFR
ERBB2
ERBB3
FLT4
GOLGA2
GRB2
KRT31
KRT40
NTRK1
NTRK2
RET
SH3GL3
Entrez ID
558
53358
HPRD ID
00171
12005
Ensembl ID
ENSG00000167601
Uniprot IDs
M0R0W6
P30530
Q92529
PDB IDs
2C5D
Enriched GO Terms of Interacting Partners
?
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Leukocyte Migration
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Blood Coagulation
Hemostasis
Cellular Response To Organic Substance
Response To Peptide Hormone
Cellular Response To Organonitrogen Compound
Locomotion
Response To Organic Substance
Response To Peptide
Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Cellular Response To Insulin Stimulus
Regulation Of Body Fluid Levels
Cellular Response To Hormone Stimulus
Cell Migration
Wound Healing
Movement Of Cell Or Subcellular Component
Insulin Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Signal Transduction
Cell Motility
Response To Insulin
Response To Wounding
Regulation Of Phosphorylation
Immune System Process
Signaling
Platelet Activation
Cell Communication
Regulation Of Kinase Activity
Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Organonitrogen Compound
Fc-epsilon Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Protein Phosphorylation
Peptidyl-amino Acid Modification
Regulation Of Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Neurogenesis
Nervous System Development
Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorylation
Phosphorylation
Phosphatidylinositol-mediated Signaling
Intracellular Signal Transduction
Cellular Response To Growth Factor Stimulus
Neuron Development
Response To Growth Factor
Regulation Of MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Catalytic Activity
Regulation Of Protein Phosphorylation
Generation Of Neurons
Anatomical Structure Development
Positive Regulation Of Protein Phosphorylation
Neuron Differentiation
Cell Surface Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Signal Transduction
System Development
Locomotion
Cell Development
Positive Regulation Of Synaptic Transmission, Glutamatergic
Developmental Process
Cellular Response To Organic Substance
Positive Regulation Of Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Signaling
Positive Regulation Of Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Cell Communication
Regulation Of Apoptotic Process
Movement Of Cell Or Subcellular Component
Tagcloud
?
antiapoptotic
ark
augmented
ax1
cascades
coincubation
erk
forebrain
gas6
gn10
gnrh
gt1
mek
migrating
olfactory
pd98059
phosphoinositide
pi3
postmigratory
programmed
protects
rescued
starved
threonine
tyro7
ufo
windows
withdrawal
wortmannin
Tagcloud (Difference)
?
antiapoptotic
ark
augmented
ax1
cascades
coincubation
erk
forebrain
gas6
gn10
gnrh
gt1
mek
migrating
olfactory
pd98059
phosphoinositide
pi3
postmigratory
programmed
protects
rescued
starved
threonine
tyro7
ufo
windows
withdrawal
wortmannin
Tagcloud (Intersection)
?