AXL and GAS6

Number of citations of the paper that reports this interaction (PubMedID 16362042)
42

Data Source:
HPRD (in vitro)

		AXL	GAS6
Description		AXL receptor tyrosine kinase	growth arrest specific 6
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Receptor Complex Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Virus Receptor Activity Phosphatidylserine Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Phosphatidylserine Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Receptor Ligand Activity
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Immune System Process Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Positive Regulation Of Signal Transduction Negative Regulation Of Macrophage Cytokine Production Cell Migration Forebrain Cell Migration Cell Differentiation Platelet Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Mononuclear Cell Differentiation Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Glomerular Filtration Protein Phosphorylation Phagocytosis Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Cell Differentiation Animal Organ Regeneration Cell-substrate Adhesion Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Cellular Response To Interferon-alpha B Cell Chemotaxis Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Fibroblast Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phagocytosis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		VEGFA-VEGFR2 Pathway	Platelet degranulation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Fostamatinib Gilteritinib
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 31170924) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32154731 32203549)	Anorectal malformation ( 31136621) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Glycated hemoglobin levels ( 34059833 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 29083408) Triglyceride levels ( 32154731 32203549) Triglycerides ( 27036123 30275531)
Interacting Genes		24 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3 UBC	3 interacting genes: AXL MERTK TYRO3
Entrez ID		558	2621
HPRD ID		00171	02705
Ensembl ID		ENSG00000167601	ENSG00000183087
Uniprot IDs		M0R0W6 P30530	B4DZY7 Q14393
PDB IDs		2C5D 4RA0 5U6B 5VXZ	1H30 2C5D 4RA0 5VXZ
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Receptor Tyrosine Kinase Binding Leukocyte Activation Cell Activation Neurotrophin TRKA Receptor Binding Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Leukocyte Differentiation Positive Regulation Of Cell Activation Immune System Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Cell Activation Lymphocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Lymphocyte Differentiation Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Multicellular Organismal Process Ephrin Receptor Binding Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Process Protein Kinase Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction T Cell Activation Cell Migration Regulation Of Programmed Cell Death Protein Phosphatase Binding Response To Growth Factor Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA	Vagina Development Female Genitalia Development Natural Killer Cell Differentiation Apoptotic Cell Clearance Genitalia Development Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Natural Killer Cell Activation Platelet Activation Phagocytosis Neutrophil Clearance Protein Tyrosine Kinase Activity Cell-substrate Adhesion Negative Regulation Of Lymphocyte Activation Receptor Complex Reproductive Structure Development Negative Regulation Of Leukocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Activation Ovulation Cycle Lymphocyte Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Viral Life Cycle Mononuclear Cell Differentiation Leukocyte Differentiation Secretion By Cell Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Activation Male Gamete Generation Spermatogenesis Forebrain Cell Migration Protein Kinase Activity Secretion Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Gamete Generation Negative Regulation Of Leukocyte Apoptotic Process Leukocyte Activation Nervous System Development Positive Regulation Of Viral Process Import Into Cell Kinase Activity Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Virus Receptor Activity Regulation Of Viral Life Cycle Cell Adhesion Neuron Apoptotic Process
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