AXL and ADAM10

Number of citations: 70 (PubMedID 16227584)
Data Source: HPRD (in vivo)

		AXL	ADAM10
Name		AXL receptor tyrosine kinase	ADAM metallopeptidase domain 10
Structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Receptor Complex Extracellular Exosome	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Postsynaptic Density Membrane Clathrin-coated Vesicle Axon Dendrite Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Pore Complex Extracellular Exosome Anchoring Junction Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Virus Receptor Activity Phosphatidylserine Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metallodipeptidase Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Immune System Process Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Positive Regulation Of Signal Transduction Negative Regulation Of Macrophage Cytokine Production Cell Migration Forebrain Cell Migration Cell Differentiation Platelet Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Mononuclear Cell Differentiation Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process	In Utero Embryonic Development Proteolysis Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Adherens Junction Organization Response To Tumor Necrosis Factor Epidermal Growth Factor Receptor Ligand Maturation Monocyte Activation Amyloid Precursor Protein Catabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Cochlea Development Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Signaling Receptor Ligand Precursor Processing Regulation Of Vasculature Development Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		VEGFA-VEGFR2 Pathway	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation
Drugs		Fostamatinib Gilteritinib	XL784
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) HDL cholesterol ( 31170924 ) Heel bone mineral density ( 30598549 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Triglyceride levels ( 32154731 32203549 )	Alzheimer's disease (late onset) ( 30820047 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840 ) Apolipoprotein A1 levels ( 32203549 ) Chronotype ( 30696823 ) Diffusing capacity of carbon monoxide ( 30694715 ) Family history of Alzheimer's disease ( 30617256 ) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355 ) Metabolite levels ( 23823483 ) Schizophrenia ( 30285260 )
Interacting Genes		24 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3 UBC	7 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
Entrez ID		558	102
HPRD ID		00171	03723
Ensembl ID		ENSG00000167601	ENSG00000137845
Uniprot IDs		M0R0W6 P30530	O14672
PDB IDs		2C5D 4RA0 5U6B 5VXZ	6BDZ 6BE6 8ESV
GO Terms Enriched among Interactors		Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Receptor Tyrosine Kinase Binding Leukocyte Activation Cell Activation Neurotrophin TRKA Receptor Binding Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Leukocyte Differentiation Positive Regulation Of Cell Activation Immune System Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Cell Activation Lymphocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Lymphocyte Differentiation Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Multicellular Organismal Process Ephrin Receptor Binding Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Process Protein Kinase Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction T Cell Activation Cell Migration Regulation Of Programmed Cell Death Protein Phosphatase Binding Response To Growth Factor Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Neuron Projection Guidance Axon Guidance Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Endocytosis Regulation Of Developmental Process Regulation Of Cell Adhesion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Regulation Of Cell Differentiation Leukocyte Differentiation Tissue Remodeling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Fasciculation Of Motor Neuron Axon Endothelial Tip Cell Fate Specification Cerebellar Purkinje Cell Layer Structural Organization Positive Regulation Of Cellular Component Organization Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Plasma Membrane Neuron Projection Development Notochord Formation Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Side Of Membrane Fasciculation Of Sensory Neuron Axon Receptor Ligand Activity Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Compartment Pattern Specification Lateral Inhibition Blood Vessel Endothelial Cell Fate Specification Endothelial Cell Fate Specification Regulation Of Vesicle-mediated Transport Positive Regulation Of Skeletal Muscle Tissue Growth Loop Of Henle Development Somite Specification Positive Regulation Of Endocytosis Positive Regulation Of Pinocytosis Kinase Activity Neutrophil Clearance Cell-substrate Adhesion