AXL

Name	AXL receptor tyrosine kinase
Structure
Interactors	24 interactors: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3 UBC
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Virus Receptor Activity Phosphatidylserine Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Immune System Process Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Positive Regulation Of Signal Transduction Negative Regulation Of Macrophage Cytokine Production Cell Migration Forebrain Cell Migration Cell Differentiation Platelet Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Mononuclear Cell Differentiation Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways	VEGFA-VEGFR2 Pathway
Drugs	Fostamatinib Gilteritinib
GWAS	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) HDL cholesterol ( 31170924 ) Heel bone mineral density ( 30598549 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Triglyceride levels ( 32154731 32203549 )
Entrez ID	558
HPRD ID	00171
Ensembl ID	ENSG00000167601
Uniprot IDs	M0R0W6 P30530
PDB IDs	2C5D 4RA0 5U6B 5VXZ
GO Terms Enriched among Interactors ?	Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Receptor Tyrosine Kinase Binding Leukocyte Activation Cell Activation Neurotrophin TRKA Receptor Binding Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Leukocyte Differentiation Positive Regulation Of Cell Activation Immune System Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Cell Activation Lymphocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Lymphocyte Differentiation Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Multicellular Organismal Process Ephrin Receptor Binding Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Process Protein Kinase Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction T Cell Activation Cell Migration Regulation Of Programmed Cell Death Protein Phosphatase Binding Response To Growth Factor Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA