USP18 and IFNAR2

Number of citations of the paper that reports this interaction (PubMedID 28165510)
79

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		USP18	IFNAR2
Description		ubiquitin specific peptidase 18	interferon alpha and beta receptor subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity ISG15-specific Peptidase Activity Molecular Adaptor Activity	Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Protein Kinase Binding Cytokine Binding Type I Interferon Binding
	Biological Process	Proteolysis Response To Bacterium Protein Deubiquitination Regulation Of Protein Stability Response To Stilbenoid Regulation Of Inflammatory Response Response To Other Organism Negative Regulation Of Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Response To Interferon-alpha Response To Interferon-beta Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus
Pathways		ISG15 antiviral mechanism TAK1-dependent IKK and NF-kappa-B activation Ub-specific processing proteases Regulation of IFNA/IFNB signaling Regulation of NF-kappa B signaling
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin Ropeginterferon alfa-2b
Diseases
GWAS		Systemic lupus erythematosus ( 33272962)	Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) COVID-19 ( 33949668) Crohn's disease ( 23128233) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)
Interacting Genes		6 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17	15 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKAR2A PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		11274	3455
HPRD ID		06136	03850
Ensembl ID		ENSG00000184979	ENSG00000159110
Uniprot IDs		Q9UMW8	P48551 Q9BUA0
PDB IDs			1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Bone Mineralization Cell Proliferation Involved In Heart Valve Development Perforant Pathway To Dendrate Granule Cell Synapse Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Ossification Embryonic Camera-type Eye Formation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Regulation Of Signal Transduction JAK Pathway Signal Transduction Adaptor Activity Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Protein Oligomerization Regulation Of Cell Communication Regulation Of Signaling Protein-cysteine S-myristoyltransferase Activity ISG15-protein Conjugation Protein-cysteine S-stearoyltransferase Activity Cardiac Neural Crest Cell Development Involved In Heart Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cranial Suture Morphogenesis Mitral Valve Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Fatty Acid Beta-oxidation Outer Ear Morphogenesis	Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Cellular Response To Virus Cytokine-mediated Signaling Pathway Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Defense Response To Virus Response To Other Organism Cytokine Receptor Binding Response To External Biotic Stimulus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Response To Exogenous DsRNA Response To DsRNA Interleukin-10-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Adaptive Immune Response Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT B Cell Activation Involved In Immune Response T Cell Activation Involved In Immune Response B Cell Activation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Cellular Response To Interferon-beta Positive Regulation Of Protein Localization ISGF3 Complex Response To Interferon-beta Immune Response Lymphocyte Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Leukocyte Activation Involved In Immune Response Defense Response Regulation Of Protein Localization To Nucleus Cell Activation Involved In Immune Response Interleukin-23-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Signal Transduction Regulation Of Immune System Process Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Negative Regulation Of Immune Response Cytokine Activity
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