USP18 and ISG15

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		USP18	ISG15
Gene Name		ubiquitin specific peptidase 18	ISG15 ubiquitin-like modifier
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Extracellular Region Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding ISG15-specific Protease Activity	Protein Binding Protein Tag
	Biological Process	Protein Deubiquitination Cytokine-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process	Viral Process Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Regulation Of Interferon-gamma Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		Regulation of IFNA signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: IFNAR2 ISG15 TRIM54 ZDHHC17	4 interactors: UBA7 UBE2E2 USP18 USP21
Entrez ID		11274	9636
HPRD ID		06136	00958
Ensembl ID		ENSG00000184979	ENSG00000187608
Uniprot IDs		Q53Y90 Q9UMW8	P05161
PDB IDs			1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL
Enriched GO Terms of Interacting Partners?		Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Response To Virus ISG15-protein Conjugation Cytokine-mediated Signaling Pathway Signal Transduction Response To Interferon-alpha Signaling Lipoprotein Transport Positive Regulation Of Erythrocyte Differentiation Magnesium Ion Transport Cellular Response To Cytokine Stimulus Cell Communication Protein Palmitoylation Response To Cytokine Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Microtubule Depolymerization Regulation Of Erythrocyte Differentiation Cellular Response To Stimulus Innate Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Genome Replication Negative Regulation Of Microtubule Polymerization Or Depolymerization JAK-STAT Cascade	ISG15-protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Catabolic Process Cytokine-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Protein Metabolic Process Histone Deubiquitination Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Proteolysis Response To Cytokine Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Innate Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cytokine-mediated Signaling Pathway Immune Response Defense Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Type I Interferon Production Response To Type I Interferon Positive Regulation Of Mitotic Cell Cycle
Tagcloud ?		appearance downregulating egress exploits g3bp1 granule granules hairpin hcv illustrate infectious infectivity interferon inverse machinery mxa opting rasgap sg sgs sh3 shrna tia tia1 tiar titers triggering triggers ways	arborization asparate blocking branching cns corroborate dendritic dysfunction engagement evident extend glun2a glun2b hand ifnalpha ifnar indicators indirect initially interferon ko neurocognitive neuroinflammation neurotoxic neurotoxicity nmdar partially protect stat1
Tagcloud (Difference) ?		appearance downregulating egress exploits g3bp1 granule granules hairpin hcv illustrate infectious infectivity inverse machinery mxa opting rasgap sg sgs sh3 shrna tia tia1 tiar titers triggering triggers ways	arborization asparate blocking branching cns corroborate dendritic dysfunction engagement evident extend glun2a glun2b hand ifnalpha ifnar indicators indirect initially ko neurocognitive neuroinflammation neurotoxic neurotoxicity nmdar partially protect stat1
Tagcloud (Intersection) ?		interferon