NANOS1 and GRIN1

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		NANOS1	GRIN1
Gene Name		nanos homolog 1 (Drosophila)	glutamate receptor, ionotropic, N-methyl D-aspartate 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Dendrite Membrane Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Translation Repressor Activity	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Glycine Binding Glutamate Binding Enzyme Binding Voltage-gated Cation Channel Activity Glutamate Receptor Binding Neurotransmitter Binding Protein Heterodimerization Activity
	Biological Process	Epithelial Cell Migration Cell Migration Negative Regulation Of Translation Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Cellular Calcium Ion Homeostasis Synaptic Transmission Axon Guidance Respiratory Gaseous Exchange Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Propylene Metabolic Process Sensory Perception Of Pain Pons Maturation Cerebral Cortex Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription From RNA Polymerase II Promoter Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Tetramerization Response To Calcium Ion Regulation Of Synapse Assembly Calcium Ion Homeostasis Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition Male Mating Behavior Response To Fungicide Calcium Ion Transmembrane Transport Cellular Response To Manganese Ion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways			EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran Agmatine
Diseases
GWAS			Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		3 interactors: GRIN1 GRIN2D PUM2	53 interactors: ACTN2 AKAP9 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B
Entrez ID		340719	2902
HPRD ID		16302	15926
Ensembl ID		ENSG00000188613	ENSG00000176884
Uniprot IDs		Q8WY41	Q05586 Q59GW0 Q5VSF9
PDB IDs			2HQW 2NR1 3BYA
Enriched GO Terms of Interacting Partners?		Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Adult Locomotory Behavior Neuromuscular Process Propylene Metabolic Process Adult Behavior Olfactory Learning Locomotory Behavior Pons Maturation Cellular Response To Manganese Ion Conditioned Taste Aversion Male Mating Behavior Response To Fungicide Olfactory Behavior Single-organism Behavior Pons Development Stress Granule Assembly Synaptic Transmission Behavior Chemosensory Behavior Prepulse Inhibition Response To Manganese Ion Suckling Behavior Regulation Of Respiratory Gaseous Exchange Regulation Of Sensory Perception Of Pain Regulation Of Long-term Neuronal Synaptic Plasticity Mating Behavior Positive Regulation Of Excitatory Postsynaptic Membrane Potential Response To Amphetamine Cell-cell Signaling Response To Morphine Social Behavior Positive Regulation Of Membrane Potential Long-term Memory Response To Amine Mating Neurological System Process Respiratory Gaseous Exchange Regulation Of Neurological System Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Synapse Assembly Visual Learning Visual Behavior Ion Transmembrane Transport Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential	Synaptic Transmission Cell-cell Signaling Nervous System Development Signaling Locomotion Cell Communication Neurogenesis Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Generation Of Neurons Neuron Projection Development Neuron Development Developmental Process Cell Development Neuron Differentiation Response To External Stimulus Signal Transduction Cell Projection Organization Movement Of Cell Or Subcellular Component Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development System Development Cellular Response To Stimulus Anatomical Structure Development Axon Development Axon Guidance Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Cellular Response To Organic Substance Response To Wounding Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Learning Response To Stimulus Regulation Of Signaling Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cell Projection Morphogenesis Single-organism Behavior Cellular Response To Growth Factor Stimulus Learning Or Memory
Tagcloud ?		antagonistic capabilities cdk6 demethylase demethylases depleted dimethylated dysregulated ectopic fbxl11 h3k36 hdac3 invasion invasiveness jhdm1a kdm2a methyltransferases nsclc occupied overexpressing recovered releases removing represses rescued substantially transcriptionally tumorigenic tumorigenicity
Tagcloud (Difference) ?		antagonistic capabilities cdk6 demethylase demethylases depleted dimethylated dysregulated ectopic fbxl11 h3k36 hdac3 invasion invasiveness jhdm1a kdm2a methyltransferases nsclc occupied overexpressing recovered releases removing represses rescued substantially transcriptionally tumorigenic tumorigenicity
Tagcloud (Intersection) ?