NANOS1 and GRIN2D

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		NANOS1	GRIN2D
Gene Name		nanos homolog 1 (Drosophila)	glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Plasma Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Translation Repressor Activity	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding
	Biological Process	Epithelial Cell Migration Cell Migration Negative Regulation Of Translation Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Startle Response Signal Transduction Synaptic Transmission Adult Locomotory Behavior Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Sensory Perception Of Pain
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Tenocyclidine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GRIN1 GRIN2D PUM2	33 interactors: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA INADL MAP2 MAP2K2 NANOS1 NF1 PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		340719	2906
HPRD ID		16302	04095
Ensembl ID		ENSG00000188613	ENSG00000105464
Uniprot IDs		Q8WY41	O15399 Q59G17
PDB IDs
Enriched GO Terms of Interacting Partners?		Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Adult Locomotory Behavior Neuromuscular Process Propylene Metabolic Process Adult Behavior Olfactory Learning Locomotory Behavior Pons Maturation Cellular Response To Manganese Ion Conditioned Taste Aversion Male Mating Behavior Response To Fungicide Olfactory Behavior Single-organism Behavior Pons Development Stress Granule Assembly Synaptic Transmission Behavior Chemosensory Behavior Prepulse Inhibition Response To Manganese Ion Suckling Behavior Regulation Of Respiratory Gaseous Exchange Regulation Of Sensory Perception Of Pain Regulation Of Long-term Neuronal Synaptic Plasticity Mating Behavior Positive Regulation Of Excitatory Postsynaptic Membrane Potential Response To Amphetamine Cell-cell Signaling Response To Morphine Social Behavior Positive Regulation Of Membrane Potential Long-term Memory Response To Amine Mating Neurological System Process Respiratory Gaseous Exchange Regulation Of Neurological System Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Synapse Assembly Visual Learning Visual Behavior Ion Transmembrane Transport Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential	Nervous System Development Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Development Locomotion Generation Of Neurons Intracellular Signal Transduction Neuron Projection Development Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Organization Signaling Cell Morphogenesis Involved In Differentiation Axonogenesis MyD88-independent Toll-like Receptor Signaling Pathway Neuron Development Cell Communication Apoptotic Process Response To Organic Substance Signal Transduction Axon Guidance Axon Development Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Death Toll-like Receptor 4 Signaling Pathway Death Regulation Of Neuron Death Developmental Process Neuron Projection Morphogenesis Response To Ammonium Ion Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Response To Morphine Regulation Of Intracellular Signal Transduction Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development Response To External Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		antagonistic capabilities cdk6 demethylase demethylases depleted dimethylated dysregulated ectopic fbxl11 h3k36 hdac3 invasion invasiveness jhdm1a kdm2a methyltransferases nsclc occupied overexpressing recovered releases removing represses rescued substantially transcriptionally tumorigenic tumorigenicity	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		antagonistic capabilities cdk6 demethylase demethylases depleted dimethylated dysregulated ectopic fbxl11 h3k36 hdac3 invasion invasiveness jhdm1a kdm2a methyltransferases nsclc occupied overexpressing recovered releases removing represses rescued substantially transcriptionally tumorigenic tumorigenicity	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?