NANOS1 and PUM2

Number of citations of the paper that reports this interaction (PubMedID 12690449)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NANOS1	PUM2
Description		nanos C2HC-type zinc finger 1	pumilio RNA binding family member 2
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GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Translation Repressor Activity Metal Ion Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Pumilio-response Element Binding LncRNA Binding
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Epithelial Cell Migration Cell Migration Negative Regulation Of Translation Oogenesis MRNA Destabilization Cerebellar Neuron Development	Skeletal System Development Hair Follicle Development Regulation Of Translation Mitochondrion Organization Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Respiratory Electron Transport Chain Stress Granule Assembly MiRNA Processing Regulation Of MRNA Stability Positive Regulation Of Sprouting Of Injured Axon Chromosome Organization Regulation Of Chromosome Segregation Adipose Tissue Development Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Regulation Of Postsynapse Assembly Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intracellular MRNA Localization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Neddylation
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Keratoconus ( 33649486) Serum alkaline phosphatase levels ( 33547301)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		3 interacting genes: GRIN1 GRIN2D PUM2	25 interacting genes: AURKA COPS5 DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1
Entrez ID		340719	23369
HPRD ID		16302	09527
Ensembl ID		ENSG00000188613	ENSG00000055917
Uniprot IDs		Q8WY41	B7ZL34 Q8TB72
PDB IDs		4CQO	3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Import Into Cytosol Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Response To Amino Acid Regulation Of Nervous System Process Propylene Metabolic Process Pumilio-response Element Binding Positive Regulation Of Synaptic Transmission Monoatomic Ion Channel Activity Calcium-mediated Signaling Response To Glycine Positive Regulation Of Sprouting Of Injured Axon Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Glycine-gated Cation Channel Activity Postsynaptic Membrane Brain Development Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Signaling Receptor Activity Positive Regulation Of Signal Transduction Regulation Of Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Regulation Of Intracellular MRNA Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Trans-synaptic Signaling Synaptic Signaling Voltage-gated Monoatomic Cation Channel Activity Cellular Response To L-glutamate Positive Regulation Of Axon Regeneration Glycine Binding Regulation Of Monoatomic Ion Transport Glutamate-gated Receptor Activity Neurotransmitter Receptor Complex	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Translation Activator Activity Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization RNA Destabilization Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Translational Initiation Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Connective Tissue Replacement Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process MRNA Stabilization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of MRNA Catabolic Process RNA Stabilization
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