C1orf174 and COPS6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		C1orf174	COPS6
Description		chromosome 1 open reading frame 174	COP9 signalosome subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity
	Biological Process		Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways			DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Verbal declarative memory ( 25648963)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: AKT1 APP COPS6 EEF1G GOLM1 IKZF1 KAT5 MEOX2 TERF2IP	95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		339448	10980
HPRD ID		17353	16735
Ensembl ID		ENSG00000198912	ENSG00000168090
Uniprot IDs		A0A7P0TAC3 Q8IYL3	Q7L5N1
PDB IDs			4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Metabolic Process CGAS/STING Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Response To Nerve Growth Factor Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Lymphocyte Migration Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cellular Response To Stress Regulation Of TRNA Methylation Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Histone H2AK5 Acetyltransferase Activity Negative Regulation Of DNA Recombination Regulation Of DNA Metabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Cell Activation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of DNA-templated Transcription Mammalian Oogenesis Stage Regulation Of RNA Biosynthetic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Organelle Organization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Innate Immune Response Maintenance Of Protein Location In Mitochondrion Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Postsynapse Organization TRNA (guanine-N7)-methylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process TORC2 Complex Binding	Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling
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