DUSP1 and MAPK8

Number of citations of the paper that reports this interaction (PMID 11278799)
52

Data Source:
HPRD (two hybrid)

		DUSP1	MAPK8
Gene Name		dual specificity phosphatase 1	mitogen-activated protein kinase 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Protein Serine/threonine Kinase Activity JUN Kinase Activity Protein Binding ATP Binding Enzyme Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding
	Biological Process	Inactivation Of MAPK Activity Endoderm Formation Protein Dephosphorylation Response To Oxidative Stress Response To Light Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Response To Testosterone Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Response To Glucocorticoid Negative Regulation Of Meiotic Cell Cycle Response To CAMP Response To Calcium Ion Negative Regulation Of ERK1 And ERK2 Cascade Mitotic Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of DNA Biosynthetic Process	Ossification Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Response To Stress JNK Cascade JUN Phosphorylation Response To UV Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Histone Deacetylation Negative Regulation Of Protein Binding Regulation Of Protein Localization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Response To Cadmium Ion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Deacetylase Activity Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence Activation of BH3-only proteins FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activation of BMF and translocation to mitochondria Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Programmed Cell Death MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Intrinsic Pathway for Apoptosis JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence Activation of BIM and translocation to mitochondria Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade NRAGE signals death through JNK Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CKS1B HSPA4 MAPK1 MAPK12 MAPK14 MAPK3 MAPK8 SKP2 UBB ZNRD1	134 interactors: AIMP1 APLP2 APP ATF2 BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 C11orf57 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 DUSP8 EEF2K ELK1 ELK3 ELK4 EP300 ETV1 FAM193B FZR1 GANAB GARS GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A3 HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IKBKAP IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAP3K2 MAP3K4 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SERPINB4 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219
Entrez ID		1843	5599
HPRD ID		02835	03100
Ensembl ID		ENSG00000120129	ENSG00000107643
Uniprot IDs		B4DU40 P28562	A1L4K2 P45983 Q308M2
PDB IDs			1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4L7F
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway MAPK Cascade Neurotrophin Signaling Pathway Signal Transduction By Phosphorylation Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Peptidyl-serine Phosphorylation Cell Cycle Activation Of MAPK Activity Cellular Response To Lipopolysaccharide Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Golgi Inheritance Positive Regulation Of MAP Kinase Activity Caveolin-mediated Endocytosis Ras Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Organization Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity	Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Phosphorylation Response To Stress Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Response To Growth Factor Apoptotic Process Cellular Response To Stimulus Programmed Cell Death Cellular Response To Stress Signaling Signal Transduction Cell Death Death MAPK Cascade Cell Communication Positive Regulation Of Cellular Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Signal Transduction By Phosphorylation Negative Regulation Of Cellular Metabolic Process Defense Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Cellular Process Response To Abiotic Stimulus Immune System Process Regulation Of Nitrogen Compound Metabolic Process Developmental Process
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk9 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles
Tagcloud (Intersection) ?