DUSP1

Description		dual specificity phosphatase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Growth Factor Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Endoderm Formation Negative Regulation Of Cell Adhesion Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Light Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Response To Testosterone Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Response To Glucocorticoid Negative Regulation Of Meiotic Cell Cycle Response To CAMP Response To Calcium Ion Peptidyl-serine Dephosphorylation ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Monocyte Chemotaxis Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of P38MAPK Cascade Cellular Response To Chemokine Negative Regulation Of DNA Biosynthetic Process
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Diastolic blood pressure ( 30224653) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Optic cup area ( 28073927) Ulcerative colitis ( 26192919) Vertical cup-disc ratio ( 25241763 28073927 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		15 interacting genes: AATK CKS1B HSPA4 HSPB2 MAPK1 MAPK12 MAPK14 MAPK3 MAPK8 MAPT POLR1H ROR2 SKP2 STAMBPL1 UBB
Entrez ID		1843
HPRD ID		02835
Ensembl ID		ENSG00000120129
Uniprot IDs		B4DU40 P28562
PDB IDs		6APX 6D65 6D66 6D67
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Protein Kinase Activity Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Protein Serine Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclase Activity MAPK Cascade Interleukin-34-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Golgi Inheritance ATP Binding Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Cellular Response To Starvation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Energy Homeostasis DNA Damage Response Nucleotide Binding Bergmann Glial Cell Differentiation Response To Starvation Response To Nutrient Levels Response To Stress Cellular Response To Nutrient Levels Cellular Response To Tumor Necrosis Factor Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Response To Lipopolysaccharide Schwann Cell Development Response To Growth Factor Positive Regulation Of Macrophage Chemotaxis Regulation Of Ossification Response To Tumor Necrosis Factor Response To Molecule Of Bacterial Origin Face Development Positive Regulation Of Neuroinflammatory Response Peptidyl-threonine Phosphorylation Animal Organ Formation Cellular Response To Stress ERBB2 Signaling Pathway Mitochondrion Transport Along Microtubule Positive Regulation Of Macrophage Migration
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