PPM1K

Description		protein phosphatase, Mg2+/Mn2+ dependent 1K
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Cation Binding Metal Ion Binding [3-methyl-2-oxobutanoate Dehydrogenase (lipoamide)]-phosphatase Activity
	Biological Process	Branched-chain Amino Acid Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Intracellular Signal Transduction
Pathways		Branched-chain amino acid catabolism H139Hfs13* PPM1K causes a mild variant of MSUD
Drugs
Diseases
GWAS		Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Coffee consumption (cups per day) ( 25288136) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Metabolite levels ( 22286219 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 32514006)
Interacting Genes		14 interacting genes: AATK BIRC2 ERBB3 HSF2BP HSPB2 LMTK2 MAGEA11 MYB MYO15B NTAQ1 PTK7 UBXN11 XIAP ZNF410
Entrez ID		152926
HPRD ID		15167
Ensembl ID		ENSG00000163644
Uniprot IDs		Q8N3J5
PDB IDs		2IQ1 4DA1 6AK7
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Neuron Apoptotic Process Regulation Of Protein Polyubiquitination
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