PPM1K and MYB

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PPM1K	MYB
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1K	v-myb avian myeloblastosis viral oncogene homolog
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Cytosol Nuclear Matrix
	Molecular Function	Protein Serine/threonine Phosphatase Activity Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding WD40-repeat Domain Binding
	Biological Process	Protein Dephosphorylation	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Calcium Ion Transport Blood Coagulation B Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Embryonic Digestive Tract Development Homeostasis Of Number Of Cells Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Cellular Response To Interleukin-6
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Conduct disorder (interaction) ( 18846501) Metabolite levels ( 22286219 22916037)	Beta thalassemia/hemoglobin E disease ( 20183929) HbA2 levels ( 23043469) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Mean platelet volume ( 22423221) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet counts ( 22139419 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 20927387) White blood cell count ( 20139978) White blood cell types ( 21738478)
Protein-Protein Interactions		2 interactors: BIRC2 MYB	43 interactors: BTRC CCND3 CEBPB CEBPE CHD3 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAX5 PIAS1 PML PPM1K RBX1 RPL4 RQCD1 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11
Entrez ID		152926	4602
HPRD ID		15167	01810
Ensembl ID		ENSG00000163644	ENSG00000118513
Uniprot IDs		Q8N3J5	P10242 Q14025 Q708E1 Q708E9
PDB IDs		2IQ1 4DA1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Protein Monoubiquitination Regulation Of Protein K63-linked Ubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Positive Regulation Of Histone H3-K4 Methylation Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Regulation Of Necrotic Cell Death Regulation Of Histone H3-K4 Methylation Cellular Response To Interleukin-6 Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of T-helper Cell Differentiation Necroptotic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Interleukin-6 Positive Regulation Of Protein Metabolic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Immune System Process Positive Regulation Of Histone Methylation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Embryonic Digestive Tract Development Necrotic Cell Death Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Regulation Of Histone Methylation Thymus Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Histone Modification Execution Phase Of Apoptosis Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Defense Response To Virus	RNA Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Protein Sumoylation Cellular Protein Modification Process Rhythmic Process Protein Modification By Small Protein Conjugation Developmental Process Peptidyl-lysine Modification PML Body Organization Cell Cycle Regulation Of Signal Transduction Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process
Tagcloud ?			amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates
Tagcloud (Difference) ?			amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates
Tagcloud (Intersection) ?