HMGB2 and MYL6

Number of citations of the paper that reports this interaction (PubMedID 31694235)
108

Data Source:
BioGRID (two hybrid)

		HMGB2	MYL6
Description		high mobility group box 2	myosin light chain 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytosol Brush Border Membrane Myosin Complex Myosin II Complex Unconventional Myosin Complex Vesicle Extracellular Exosome
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	Microfilament Motor Activity Cytoskeletal Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis	Muscle Contraction Skeletal Muscle Tissue Development Muscle Filament Sliding
Pathways		Apoptosis induced DNA fragmentation	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS			Asthma ( 31619474)
Interacting Genes		54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668	11 interacting genes: ADAMTS12 CEBPA DNAJB9 EWSR1 FNDC3B GLP1R GSK3B HMGB2 MLH1 MOB4 NUDT21
Entrez ID		3148	4637
HPRD ID		01229	17618
Ensembl ID		ENSG00000164104	ENSG00000092841
Uniprot IDs		P26583	P60660
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process	Response To Peptide Response To Cytokine Positive Regulation Of Developmental Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cell Differentiation Response To Hormone Regulation Of Cell Differentiation Regulation Of Developmental Process Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Glucagon-like Peptide 1 Receptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Condensed Chromosome Somatic Cell DNA Recombination Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Pro-B Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Immunoglobulin Production Positive Regulation Of Gene Expression Response To Vitamin Response To Vitamin B2 C/EBP Complex Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Apoptotic Signaling Pathway Non-sequence-specific DNA Binding, Bending Regulation Of Immunoglobulin Production Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Stem Cell Differentiation Regulation Of Multicellular Organismal Process Regulation Of Stem Cell Proliferation Response To Lipid CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Glucagon Receptor Activity Negative Regulation Of Signal Transduction Male Meiosis Chromosome Segregation
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