HMGB2 and NOP53

Number of citations of the paper that reports this interaction (PubMedID 32867128)
136

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid)

		HMGB2	NOP53
Description		high mobility group box 2	NOP53 ribosome biogenesis factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol RDNA Heterochromatin
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	P53 Binding RNA Binding Protein Binding 5S RRNA Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis	Ribosomal Large Subunit Assembly Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Phosphorylation DNA Repair RRNA Processing DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Ribosome Biogenesis Regulation Of Apoptotic Process Protein Stabilization Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Localization To Nucleolus Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Protein Localization To Nucleoplasm
Pathways		Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS
Interacting Genes		54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668	15 interacting genes: CCDC136 CDKN2A CEP70 CFTR GRSF1 HAP1 HMGB2 OGT PPP1CA PSMA1 SPTBN1 SRPK2 TP53 TSPYL2 UPF2
Entrez ID		3148	29997
HPRD ID		01229	16142
Ensembl ID		ENSG00000164104	ENSG00000105373
Uniprot IDs		P26583	Q9NZM5
PDB IDs			8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FLA 8FLB 8FLD 8FLE 8INE 8INF 8IPX 8IPY 8IR3
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process	Nucleolus 14-3-3 Protein Binding Autophagy Of Mitochondrion Protein-containing Complex Cytoplasm Regulation Of Carbohydrate Catabolic Process Regulation Of Cellular Localization Nucleus Organization Organelle Organization MDM2/MDM4 Family Protein Binding Replicative Senescence Developmental Process Regulation Of Glucose Metabolic Process Nuclear Body Organization Autophagy RRNA Transcription Entrainment Of Circadian Clock By Photoperiod Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Negative Regulation Of DNA Replication Disordered Domain Specific Binding Negative Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Gene Expression Cellular Component Assembly Negative Regulation Of Cell Growth Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Cellular Component Organization Anatomical Structure Formation Involved In Morphogenesis Regulation Of Programmed Necrotic Cell Death Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transporter Activity Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Growth Nucleic Acid Metabolic Process RNA Metabolic Process Ligase Inhibitor Activity Regulation Of Cell Communication Nucleus Regulation Of Signaling Catabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Double-strand Break Repair Negative Regulation Of Helicase Activity
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