HMGB2 and ZNF622

Number of citations of the paper that reports this interaction (PubMedID 29721183)
101

Data Source:
BioGRID (two hybrid)

		HMGB2	ZNF622
Description		high mobility group box 2	zinc finger protein 622
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Preribosome, Large Subunit Precursor
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Preribosome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Kinase Activity Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade
Pathways		Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS			Attention function in attention deficit hyperactive disorder ( 26174813)
Interacting Genes		54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668	9 interacting genes: APP BEND7 CDC42 HMGB2 MACROH2A1 MELK MYBL2 OGT PRKN
Entrez ID		3148	90441
HPRD ID		01229	12278
Ensembl ID		ENSG00000164104	ENSG00000173545
Uniprot IDs		P26583	Q969S3
PDB IDs			6LQM 6LSR 9GMO
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process	Regulation Of Purine Nucleotide Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Regulation Of ATP Metabolic Process Cellular Response To Manganese Ion RAGE Receptor Binding Regulation Of Small Molecule Metabolic Process Protein-containing Complex Response To Manganese Ion Cellular Component Assembly Cellular Response To Catecholamine Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Neurotransmitter Uptake Response To Catecholamine Negative Regulation Of Transcription By RNA Polymerase II Hemopoiesis Amyloid Fibril Formation Regulation Of Response To Oxidative Stress Positive Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Negative Regulation Of Gene Expression Chemoattractant Activity Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Metabolic Process Negative Regulation Of Protein Localization Condensed Chromosome Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Gene Expression Postsynapse Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Chemotaxis Positive Regulation Of Developmental Process Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Gene Expression, Epigenetic Protein-containing Complex Organization Regulation Of Glycolytic Process Negative Regulation Of RNA Metabolic Process Mitophagy Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Regulation Of Transcription By RNA Polymerase II
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