HMGB2 and HACD3

Number of citations of the paper that reports this interaction (PubMedID 29721183)
101

Data Source:
BioGRID (two hybrid)

		HMGB2	HACD3
Description		high mobility group box 2	3-hydroxyacyl-CoA dehydratase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Focal Adhesion Membrane Nuclear Membrane
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	GTPase Activator Activity Protein Binding Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding Very-long-chain (3R)-3-hydroxyacyl-CoA Dehydratase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Canonical NF-kappaB Signal Transduction JNK Cascade Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Rac Protein Signal Transduction Sphingolipid Biosynthetic Process Fatty Acid Elongation Very Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Intracellular Signal Transduction
Pathways		Apoptosis induced DNA fragmentation	Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS			Glycated hemoglobin levels ( 34059833) Hemoglobin levels ( 32327693)
Interacting Genes		54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668	3 interacting genes: HMGB2 NEAT1 RAC1
Entrez ID		3148	51495
HPRD ID		01229	11037
Ensembl ID		ENSG00000164104	ENSG00000074696
Uniprot IDs		P26583	H3BRL8 Q9P035
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process	Cell Chemotaxis Response To Molecule Of Bacterial Origin DNA Geometric Change Response To Lipopolysaccharide DNA Topological Change Positive Regulation Of Epithelial Cell Proliferation Non-sequence-specific DNA Binding, Bending Supercoiled DNA Binding Nucleus Organization Cell Motility Spermatid Nucleus Differentiation Chemotaxis Negative Regulation Of Gene Expression Kinocilium Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Interleukin-23 Production Regulation Of Interleukin-23 Production Regulation Of Ovarian Follicle Development Regulation Of ERK5 Cascade G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Rho GDP-dissociation Inhibitor Binding Auditory Receptor Cell Morphogenesis Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Neuron Maturation Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Embryonic Olfactory Bulb Interneuron Precursor Migration Thioesterase Binding Erythrocyte Enucleation Cerebral Cortex GABAergic Interneuron Development Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Involved In Heart Morphogenesis Engulfment Of Apoptotic Cell Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Tangential Migration From The Subventricular Zone To The Olfactory Bulb Third Ventricle Development RISC Complex Binding Positive Regulation Of Synoviocyte Proliferation Paraspeckles Positive Regulation Of MiRNA Catabolic Process Regulation Of MRNA Export From Nucleus MiRNA Inhibitor Activity Via Base-pairing LncRNA-mediated Post-transcriptional Gene Silencing Locomotion Regulation Of Epithelial Cell Proliferation RAGE Receptor Binding Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Receptor Clustering Negative Regulation Of Fibroblast Migration Midbrain Dopaminergic Neuron Differentiation
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