HMGB2 and ZNF428

Number of citations of the paper that reports this interaction (PubMedID 32867128)
136

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		HMGB2	ZNF428
Description		high mobility group box 2	zinc finger protein 428
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Endothelial Cell Proliferation Immune System Process Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Spermatogenesis Spermatid Nucleus Differentiation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hemopoiesis
Pathways		Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS
Interacting Genes		54 interacting genes: - APEX1 APP AR ARCN1 BCCIP C1QBP CACTIN CEBPA CHAF1A COMMD1 CRBN CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PCBP1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 ROCK1 RPS28 SAMM50 SET SNAPIN TBC1D25 TP53 TSNAX U2AF1 UHRF2 ZFR ZNF428 ZNF622 ZNF668	3 interacting genes: HMGB1 HMGB2 LIG4
Entrez ID		3148	126299
HPRD ID		01229	14671
Ensembl ID		ENSG00000164104	ENSG00000131116
Uniprot IDs		P26583	I6L9C8 Q96B54
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleic Acid Metabolic Process Regulation Of MiRNA Transcription DNA Metabolic Process Regulation Of MiRNA Metabolic Process DNA Binding Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA Repair Transcription Coactivator Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Transcription Regulator Complex Regulation Of Apoptotic Process Chromatin Organization Positive Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Chromatin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Estrogen Response Element Binding Regulation Of Gene Expression Nucleoplasm Cytoplasm Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Speck Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Negative Regulation Of RNA Metabolic Process	V(D)J Recombination Condensed Chromosome Somatic Cell DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining Supercoiled DNA Binding DNA Geometric Change DNA Topological Change RAGE Receptor Binding Double-strand Break Repair DNA Binding, Bending DNA Recombination Four-way Junction DNA Binding DNA Conformation Change Chromosome Organization Chemoattractant Activity Inflammatory Response To Antigenic Stimulus Base-excision Repair Positive Regulation Of Interferon-beta Production Positive Chemotaxis DNA Repair Regulation Of Interferon-beta Production Damaged DNA Binding DNA Metabolic Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Endothelial Cell Proliferation Hematopoietic Progenitor Cell Differentiation DNA Damage Response Regulation Of Cell Development Positive Regulation Of Myeloid Cell Differentiation Single-stranded DNA Binding Positive Regulation Of Cell Differentiation Lymphocyte Activation Involved In Immune Response Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Cell Population Proliferation Double-stranded DNA Binding Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Type I Interferon Production Establishment Of Integrated Proviral Latency Regulation Of Endothelial Cell Proliferation T Cell Differentiation Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Cellular Response To Lipopolysaccharide Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance DNA-binding Transcription Factor Binding Non-sequence-specific DNA Binding, Bending Establishment Of Viral Latency Cellular Response To Molecule Of Bacterial Origin
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