HMGB2 and HMGA1

Number of citations of the paper that reports this interaction (PMID 18850631)
2

Data Source:
BioGRID (far western blotting)

		HMGB2	HMGA1
Gene Name		high mobility group box 2	high mobility group AT-hook 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Protein Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Poly(A) RNA Binding RAGE Receptor Binding	DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity V(D)J Recombination Positive Regulation Of DNA Binding Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	DNA Catabolic Process, Endonucleolytic DNA Unwinding Involved In DNA Replication Base-excision Repair Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Negative Regulation Of Cell Proliferation Response To Virus Viral Process Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence
Pathways		Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase	DNA Damage/Telomere Stress Induced Senescence Vpr-mediated nuclear import of PICs HIV Infection Cellular Senescence Host Interactions of HIV factors Integration of provirus Interactions of Vpr with host cellular proteins Early Phase of HIV Life Cycle Autointegration results in viral DNA circles HIV Life Cycle Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2-LTR circle formation Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection
Drugs
Diseases
GWAS			Body mass index ( 20935630) Height ( 21998595 20881960 19396169 19343178 19893584 23563607 18391951 20397748 20189936)
Protein-Protein Interactions		20 interactors: APEX1 APP AR CHAF1A CREBBP CSNK1A1 GZMA GZMK HMGA1 NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SET TP53	60 interactors: ANXA1 ANXA2 APEX1 ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SSB SUFU SYNCRIP UPF2
Entrez ID		3148	3159
HPRD ID		01229	02829
Ensembl ID			ENSG00000137309
Uniprot IDs		P26583	P17096 Q5T6U8
PDB IDs			2EZD 2EZE 2EZF 2EZG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Chromosome Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Chromatin Organization Cellular Metabolic Process Developmental Process Lymphocyte Differentiation B Cell Differentiation Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Assembly Leukocyte Differentiation T Cell Differentiation Chromatin Assembly Or Disassembly B Cell Activation Positive Regulation Of Cell Aging Transcription Initiation From RNA Polymerase II Promoter B Cell Lineage Commitment Cell Activation Multicellular Organismal Development DNA Metabolic Process DNA Packaging Lymphocyte Activation Intracellular Receptor Signaling Pathway	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Gene Expression Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Gene Expression RNA Splicing Biosynthetic Process Negative Regulation Of Transcription, DNA-templated RNA Processing Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Regulation Of Cell Cycle Viral Process Cell Differentiation Metabolic Process DNA-templated Transcription, Initiation Cellular Response To Organic Substance Developmental Process Regulation Of Cell Differentiation
Tagcloud ?		advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Difference) ?		advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Intersection) ?