XRCC6 and SUMO2

Number of citations of the paper that reports this interaction (PubMedID 19394292)
55

Data Source:
BioGRID (pull down)

		XRCC6	SUMO2
Description		X-ray repair cross complementing 6	small ubiquitin like modifier 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm PML Body Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Lyase Activity ATP Hydrolysis Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity Scaffold Protein Binding	RNA Binding Protein Binding SUMO Transferase Activity Protein Tag Activity Ubiquitin Protein Ligase Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process Positive Regulation Of Immune System Process DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS		Asthma ( 34103634) Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)	Deep white matter hyperintensities ( 32517579) Gamma glutamyl transferase levels ( 29403010 33339817) Serum metabolite levels ( 33031748) Type 2 diabetes ( 32499647)
Interacting Genes		144 interacting genes: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCNB1 CCT3 CD40 CDCA5 CDK1 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DEAF1 DLX2 DNTT DSCR4 DUX4 DYRK1A DYSF EFNA1 EGFR EID1 EIF4ENIF1 ELF3 EP300 EPS8 ETS1 FCER2 FILNC1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HACL2 HERPUD1 HOXB7 HOXC4 HOXD4 HSF1 HTT JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 OGT PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF10 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERT TP53 UBC USP14 VAV1 VBP1 WBP4 WEE2-AS1 WRN XRCC5 YWHAZ ZBTB7A ZNF512B	459 interacting genes: AARS1 ABCF1 ABRAXAS1 ACIN1 ACTB AFG2A AFG2B AHCYL1 AHNAK AHNAK2 AIMP1 ALAS1 ANAPC1 ANAPC2 ANLN ANXA1 APRT ARF3 ARF4 ARID2 ARK2N ARRB2 ASNS ASS1 ATF7IP ATRX ATXN7 BABAM2 BAD BAZ1A BAZ1B BLM BOD1L1 BPTF BRCC3 BZW1 CAD CALM1 CARS1 CAST CCAR2 CCNE2 CCT2 CCT3 CCT4 CCT5 CCT6A CDK2 CEBPA CENPC CHAF1A CHAF1B CHAMP1 CHD3 CHD4 CHD8 CKAP5 CLTC CMTM6 COPA COPB2 COPG1 CPSF2 CPSF7 CSE1L CSNK2B CTNNBL1 CTNND1 CTR9 CUL3 CUX1 DAB2 DARS1 DAXX DCD DDX1 DDX17 DDX21 DDX39A DDX3X DDX5 DIDO1 DIP2B DNAJA1 DNM1L DNMT1 DYNC1H1 EDC4 EEF1A1 EEF1A2 EEF1G EEF2 EFTUD2 EGLN3 EHD4 EHMT1 EIF4A1 EIF4A2 EIF4G1 EIF4G2 EIF5A ELAC2 EME1 EMG1 EML3 ENO1 EP300 EP400 EPPK1 EPRS1 ERCC4 ERCC6 EXOSC10 EXOSC9 EZR FARSB FASN FBXO38 FLNA FLNB FOS GALK1 GAPVD1 GATAD2B GCN1 GEMIN5 GPATCH8 GTF2I GTF3C1 GTF3C2 GTF3C4 GYS1 HCFC1 HDAC1 HDAC2 HDAC4 HDAC9 HDLBP HIPK2 HK2 HMGXB4 HNRNPA0 HNRNPA1L2 HNRNPA2B1 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPLL HNRNPM HNRNPR HNRNPU HOMEZ HP1BP3 HPS6 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA5 HSPA8 HSPA9 HSPB1 HSPD1 HUWE1 IARS1 ILK IMPDH2 INTS3 IPO5 IQGAP1 JUN KALRN KARS1 KDM1A KDM5C KIF11 KIF18B KIF23 KIF2A KIF2C KIF4A KIF5B KPNA2 KRT8 LARS1 LAS1L LEF1 LMNA LMO7 MAF1 MAP4 MARS1 MAST2 MCM3 MCM4 MDC1 MDN1 MKI67 MMS19 MORC3 MPI MRE11 MSH2 MSH3 MSH6 MSX1 MTA1 MTA2 MTHFD1 MUS81 MYB MYG1 NAP1L1 NARS1 NAT10 NBN NCAPD2 NCAPD3 NCAPG NCAPH2 NCL NCOR1 NFATC2IP NFE2L2 NIBAN2 NIPBL NOL9 NONO NOP2 NPM1 NSUN2 NUMA1 NUP107 NUP160 NUP214 ORC3 P4HA1 P4HB PAF1 PALLD PARN PARP1 PBRM1 PCBP2 PDCD4 PDCD6IP PDS5A PELP1 PFKL PFKM PFKP PGK1 PHF3 PHF5A PHF8 PIAS1 PIAS2 PIAS3 PIAS4 PKM PKN2 PLEC PML POGZ POLA1 POLD1 POLR2A PPIE PPP1CC PPP2R1A PRC1 PRDX6 PRKDC PRPF6 PRPF8 PSMC1 PSMC3 PSMC4 PSMC5 PTBP1 RAD21 RAD50 RAD51 RAD54L2 RAN RANBP2 RANGAP1 RARS1 RBBP4 RBBP7 RCC1 RCOR1 RCOR2 RCOR3 RFC2 RFC4 RFC5 RIF1 RNF111 RNF168 RNF20 RNF213 RNF216 RNF4 RNF8 RPL10 RPL3 RPL4 RPS3 RPS4X RPS6KA3 RREB1 RRM1 RUVBL1 S100A10 SAE1 SAFB SAFB2 SALL1 SAMHD1 SARS1 SART1 SCAF11 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SERPINB6 SETDB1 SETX SF3A1 SF3B1 SF3B2 SIMC1 SIN3A SIRT1 SLC22A2 SLX4IP SMARCA4 SMARCAD1 SMC1A SMC3 SMC4 SMCHD1 SND1 SNRNP200 SNW1 SNX27 SOBP SOX10 SOX6 SP1 SP100 SPR SPTAN1 SPTBN1 SRCAP SRP68 SRRM2 SRRT SSRP1 STAG2 STIP1 STRAP SUPT16H SUPT5H SYMPK SYNCRIP TAF1 TAGLN2 TCERG1 TCP1 TDG TDP2 TEAD3 TEX10 TK1 TLN1 TMPO TNIP1 TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TPR TPX2 TRAF1 TRIM25 TRIM26 TRIM28 TRIM63 TRIML2 TRIP13 TRMT1L TSR1 TTI1 TTLL12 TUBA1B TUBA1C TUBA4A TUBB TUBB4A TUBB4B TUBB6 U2AF2 UBA1 UBA2 UBAP2L UBE2I UBR4 UIMC1 UMPS UPF1 USP11 USP25 USP28 USP36 USP48 USP5 USP7 USP9X USPL1 VARS1 VIM WAPL WASHC2C WDHD1 WRN XAB2 XPNPEP1 XPO1 XPO5 XRCC5 XRCC6 YWHAQ ZBED1 ZBTB2 ZBTB25 ZBTB33 ZBTB39 ZC3H11A ZCCHC12 ZCCHC7 ZHX1 ZMAT3 ZMIZ2 ZMYM2 ZMYM3 ZMYM4 ZMYM5 ZMYND8 ZNF451 ZNF496 ZNF638
Entrez ID		2547	6613
HPRD ID		01071	04332
Ensembl ID		ENSG00000196419	ENSG00000188612
Uniprot IDs		B1AHC9 B4DE32 B4E356 P12956	P61956
PDB IDs		1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE 7AXZ 7K0Y 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4	1WM2 1WM3 1WZ0 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2N1W 2N9E 2RPQ 3UIN 3UIO 3ZO5 4BKG 4NPN 5D2M 5ELU 5EQL 5GHB 5GHC 6JXW 6JXX 7ZJV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Response To Stress DNA Metabolic Process DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Protein-containing Complex Regulation Of Protein Stability Chromatin Negative Regulation Of Programmed Cell Death Double-strand Break Repair Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II	Nucleus Nucleoplasm Nucleic Acid Metabolic Process RNA Binding Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Metabolic Process DNA Repair ATP Hydrolysis Activity Regulation Of Metabolic Process DNA Damage Response ATP Binding Nucleotide Binding Cellular Response To Stress Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA Metabolic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Chromosome Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Nucleolus Cytoplasm Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Chromatin Binding Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Metabolic Process Double-strand Break Repair
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