XRCC6 and CDKN1A

Number of citations of the paper that reports this interaction (PubMedID 9798959)
0

Data Source:
HPRD (in vivo)

		XRCC6	CDKN1A
Description		X-ray repair cross complementing 6	cyclin dependent kinase inhibitor 1A
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body Protein-containing Complex PCNA-p21 Complex
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Lyase Activity ATP Hydrolysis Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity Scaffold Protein Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine/threonine Kinase Binding Protein Sequestering Activity Molecular Function Activator Activity Molecular Function Inhibitor Activity
	Biological Process	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process Positive Regulation Of Immune System Process DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Protein Import Into Nucleus DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Response To UV Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Keratinocyte Differentiation Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Amino Acid Starvation Wound Healing Tissue Regeneration Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Programmed Cell Death Keratinocyte Proliferation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Negative Regulation Of Growth Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Import Into Nucleus Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Signal Transduction By P53 Class Mediator Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Neddylation Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs			Valproic acid Arsenic trioxide
Diseases			Cervical cancer
GWAS		Asthma ( 34103634) Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)	Abdominal aortic aneurysm ( 32981348) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 30529582 31826910 22634755) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) JT interval ( 29874175) Left ventricle wall thickness ( 33495596) Left ventricular fractional shortening ( 28394258) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 31251759 31217584 30679814 27659466 27577874 25035420 21076409) Triglyceride levels ( 32203549) Triglycerides ( 27036123)
Interacting Genes		144 interacting genes: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCNB1 CCT3 CD40 CDCA5 CDK1 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DEAF1 DLX2 DNTT DSCR4 DUX4 DYRK1A DYSF EFNA1 EGFR EID1 EIF4ENIF1 ELF3 EP300 EPS8 ETS1 FCER2 FILNC1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HACL2 HERPUD1 HOXB7 HOXC4 HOXD4 HSF1 HTT JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 OGT PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF10 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERT TP53 UBC USP14 VAV1 VBP1 WBP4 WEE2-AS1 WRN XRCC5 YWHAZ ZBTB7A ZNF512B	207 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 NSUN2 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 POLD2 PPM1D PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RANBP9 RB1 RBBP4 RBM48 REL RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SCML2 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TNKS TRAF1 TRIM21 TRIM3 TRIM54 TRIM71 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431
Entrez ID		2547	1026
HPRD ID		01071	00298
Ensembl ID		ENSG00000196419	ENSG00000124762
Uniprot IDs		B1AHC9 B4DE32 B4E356 P12956	P38936
PDB IDs		1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE 7AXZ 7K0Y 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4	1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H 7KQ0 7KQ1 8GJF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Response To Stress DNA Metabolic Process DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Protein-containing Complex Regulation Of Protein Stability Chromatin Negative Regulation Of Programmed Cell Death Double-strand Break Repair Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II	Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Cytoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cyclin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Signal Transduction Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?