XRCC6 and POU2F2

Number of citations of the paper that reports this interaction (PMID 11279128)
11

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		XRCC6	POU2F2
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 6	POU class 2 homeobox 2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Telomere Cap Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Telomere Maintenance DNA Ligation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Transcription, DNA-templated Brain Development Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding V(D)J Recombination Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neurogenesis Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency	Mature B Cell Differentiation Immunoglobulin Secretion Involved In Immune Response Transcription From RNA Polymerase II Promoter Humoral Immune Response Positive Regulation Of Transcription, DNA-templated Cell Maturation
Pathways		Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		126 interactors: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 FMNL1 GAL3ST4 GSE1 GZMA GZMB H2AFX HERPUD1 HMGA2 HN1L HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11A MSX2 NAA15 NCF4 NCL NCOA6 NHP2L1 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SEP15 SERPINA2 SERPINB9 SGOL1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SPARC TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TP53 VAV1 VBP1 WBP4 WRN XRCC5 XRCC6BP1 YWHAZ ZNF512B	13 interactors: AR ESR1 GAPDH HMGA1 HMGB2 MNAT1 NR3C1 PGR POU2AF1 RXRA TBP TXNRD1 XRCC6
Entrez ID		2547	5452
HPRD ID		01071	01251
Ensembl ID		ENSG00000196419	ENSG00000028277
Uniprot IDs		B1AHC8 B1AHC9 P12956	B5ME60 E9PNC9 P09086
PDB IDs		1JEQ 1JEY 1JJR 3RZX	1HDP
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Chromosome Organization Regulation Of Cell Death Regulation Of Cellular Component Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Cell Cycle Process Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Organic Substance Cellular Response To Stress Organelle Organization Positive Regulation Of Gene Expression Gene Expression DNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Telomere Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Mitotic Cell Cycle Embryo Development Negative Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Catalytic Activity Cellular Metabolic Process Cellular Response To Organic Substance	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cellular Response To Steroid Hormone Stimulus RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Lipid Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Response To Steroid Hormone Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Reproductive Process Multicellular Organismal Reproductive Process Negative Regulation Of Biosynthetic Process Response To Lipid Multicellular Organism Reproduction Response To Organic Cyclic Compound Gland Development Reproductive Structure Development Reproductive System Development Mammary Gland Duct Morphogenesis Response To Hormone Prostate Gland Development
Tagcloud ?		brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5	aberrations aggregate arid1a broaden carries constitutes deregulation disomy dnmt3b evolving exclusive exome fl follicular hist1h1 hodgkin implicating irf8 linker massively mutated mutually oct2 profiling recurrently stably substantially transduced uniparental
Tagcloud (Difference) ?		brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5	aberrations aggregate arid1a broaden carries constitutes deregulation disomy dnmt3b evolving exclusive exome fl follicular hist1h1 hodgkin implicating irf8 linker massively mutated mutually oct2 profiling recurrently stably substantially transduced uniparental
Tagcloud (Intersection) ?