XRCC6 and PAEP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRCC6	PAEP
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 6	progestagen-associated endometrial protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Telomere Cap Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex	Extracellular Region
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity	Small Molecule Binding
	Biological Process	Telomere Maintenance DNA Ligation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Transcription, DNA-templated Brain Development Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding V(D)J Recombination Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neurogenesis Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency	Transport Multicellular Organismal Development
Pathways		Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		126 interactors: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 FMNL1 GAL3ST4 GSE1 GZMA GZMB H2AFX HERPUD1 HMGA2 HN1L HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11A MSX2 NAA15 NCF4 NCL NCOA6 NHP2L1 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SEP15 SERPINA2 SERPINB9 SGOL1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SPARC TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TP53 VAV1 VBP1 WBP4 WRN XRCC5 XRCC6BP1 YWHAZ ZNF512B	11 interactors: A2M APP COPS6 EEF1A1 GRAMD3 IGSF21 LRIF1 PTPRC SMAD3 UBE2E1 XRCC6
Entrez ID		2547	5047
HPRD ID		01071	01411
Ensembl ID		ENSG00000196419	ENSG00000122133
Uniprot IDs		B1AHC8 B1AHC9 P12956	P09466
PDB IDs		1JEQ 1JEY 1JJR 3RZX
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Chromosome Organization Regulation Of Cell Death Regulation Of Cellular Component Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Cell Cycle Process Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Organic Substance Cellular Response To Stress Organelle Organization Positive Regulation Of Gene Expression Gene Expression DNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Telomere Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Mitotic Cell Cycle Embryo Development Negative Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Catalytic Activity Cellular Metabolic Process Cellular Response To Organic Substance	Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Cell Activation Negative Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Regulation Of Humoral Immune Response Regulation Of Cell Cycle Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Platelet Degranulation Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Immunoglobulin Biosynthetic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hematopoietic Stem Cell Migration Negative Regulation Of Complement Activation, Lectin Pathway Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Viral Process Negative Regulation Of Immune Response Cellular Hyperosmotic Salinity Response Collateral Sprouting In Absence Of Injury Evasion Or Tolerance Of Host Defenses By Virus Wound Healing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Peptidase Activity Response To Ionizing Radiation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Catalytic Activity Regulation Of Cell Differentiation Regulation Of Extracellular Matrix Assembly Collateral Sprouting Axon Midline Choice Point Recognition Immune System Development Response To Wounding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?		brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5	acaca crh deregressed dgat1 fasn fertility fp fy gh1 holstein lep lgb longevity mastitis mfge8 milk mscc pft piebaldism positives pp ppargc1a proofs py relatedness sires thrsp tph1 traits
Tagcloud (Difference) ?		brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5	acaca crh deregressed dgat1 fasn fertility fp fy gh1 holstein lep lgb longevity mastitis mfge8 milk mscc pft piebaldism positives pp ppargc1a proofs py relatedness sires thrsp tph1 traits
Tagcloud (Intersection) ?