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HMGN1 and TERF2
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
HMGN1
TERF2
Description
high mobility group nucleosome binding domain 1
telomeric repeat binding factor 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Female Germ Cell Nucleus
Nucleus
Nucleoplasm
Cytoplasm
Chromosome, Telomeric Region
Telomere Cap Complex
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nuclear Body
Axon
Shelterin Complex
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Nucleosomal DNA Binding
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Pyrimidine Dimer Repair By Nucleotide-excision Repair
Transcription-coupled Nucleotide-excision Repair
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Response To UV-B
Response To UV-C
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Development, Heterochronic
Post-embryonic Camera-type Eye Morphogenesis
Regulation Of Epithelial Cell Proliferation
Telomere Maintenance
In Utero Embryonic Development
RNA-templated DNA Biosynthetic Process
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
LDL cholesterol levels (
32203549
)
Lipoprotein (a) levels (
33730874
)
Smoking status (ever vs never smokers) (
30643258
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Daytime nap (
33568662
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Interacting Genes
22 interacting genes:
CDC42
CEBPA
CHEK2
EP300
GSK3A
HMGN2
HPF1
IRF2
LIG4
MDM2
NFE2
PARP1
PPP1CC
PRKACA
PRKCA
RPS6KA3
RPS6KA4
RPS6KA5
SLC38A3
SPP1
TERF2
YWHAZ
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
Entrez ID
3150
7014
HPRD ID
01231
03610
Ensembl ID
ENSG00000205581
ENSG00000132604
Uniprot IDs
P05114
Q6NSG7
Q15554
PDB IDs
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
Enriched GO Terms of Interacting Partners
?
TORC1 Signaling
Regulation Of Nucleobase-containing Compound Metabolic Process
TOR Signaling
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Intracellular Signal Transduction
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cellular Component Organization
Regulation Of Macromolecule Metabolic Process
Response To Nutrient Levels
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Steroid Hormone
Protein Serine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Protein Domain Specific Binding
Cellular Response To Stress
Regulation Of DNA-templated Transcription
Response To Gamma Radiation
Regulation Of RNA Biosynthetic Process
Cellular Response To Lithium Ion
Regulation Of Gene Expression
Protein Serine/threonine Kinase Activity
Regulation Of Metabolic Process
Response To Lithium Ion
Chromatin Organization
Histone H3S28 Kinase Activity
Response To Hormone
Regulation Of Transcription By RNA Polymerase II
Protein Kinase Binding
Chromatin Remodeling
Negative Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Radiation
Chromosome, Telomeric Region
Nucleus
Negative Regulation Of Biosynthetic Process
Protein Kinase Activity
Protein Modification Process
Protein Phosphorylation
Nucleoplasm
Nucleus
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Chromosome, Telomeric Region
DNA Recombination
Telomere Maintenance
Chromatin Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Organization
DNA Repair
Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Recombinational Repair
Cellular Response To Stress
Regulation Of Primary Metabolic Process
DNA Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Negative Regulation Of Metabolic Process
Nuclear Speck
RNA Binding
DNA Geometric Change
Bubble DNA Binding
Chromosome Organization
Telomeric DNA Binding
Negative Regulation Of RNA Metabolic Process
Damaged DNA Binding
Nuclear Telomere Cap Complex
7SK SnRNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Cellular Response To Ionizing Radiation
Negative Regulation Of Macromolecule Biosynthetic Process
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Cytoplasm
Regulation Of DNA Recombination
Response To Ionizing Radiation
Nucleosomal DNA Binding
Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Forked DNA-dependent Helicase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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