HMGN1 and IRF2

Number of citations of the paper that reports this interaction (PubMedID 11025449)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		HMGN1	IRF2
Description		high mobility group nucleosome binding domain 1	interferon regulatory factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus
Pathways			Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 33730874) Smoking status (ever vs never smokers) ( 30643258)	Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978) Type 1 diabetes ( 34012112)
Interacting Genes		22 interacting genes: CDC42 CEBPA CHEK2 EP300 GSK3A HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	24 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFE2L2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63
Entrez ID		3150	3660
HPRD ID		01231	00962
Ensembl ID		ENSG00000205581	ENSG00000168310
Uniprot IDs		P05114 Q6NSG7	P14316
PDB IDs			8YTG
Enriched GO Terms of Interacting Partners?		TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Protein Serine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Protein Domain Specific Binding Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Gamma Radiation Regulation Of RNA Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Gene Expression Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Response To Lithium Ion Chromatin Organization Histone H3S28 Kinase Activity Response To Hormone Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Radiation Chromosome, Telomeric Region Nucleus Negative Regulation Of Biosynthetic Process Protein Kinase Activity Protein Modification Process Protein Phosphorylation	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of DNA-templated Transcription Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Cytokine Transcription Cis-regulatory Region Binding Response To Peptide Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Glucose Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Response To Hormone Defense Response Nucleoplasm Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cellular Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process
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