HMGN1 and RPS6KA5

Number of citations of the paper that reports this interaction (PubMedID 12773393)
46

Data Source:
HPRD (in vivo)

		HMGN1	RPS6KA5
Description		high mobility group nucleosome binding domain 1	ribosomal protein S6 kinase A5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Histone H2AS1 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Axon Guidance Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Regulation Of Postsynapse Organization
Pathways			ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 33730874) Smoking status (ever vs never smokers) ( 30643258)	A body shape index ( 34021172) Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: CDC42 CEBPA CHEK2 EP300 GSK3A HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CRYAA CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AC25 H2BC21 H2BC26 H2BC3 H3-4 H3C14 H3C6 H4C14 H4C16 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		3150	9252
HPRD ID		01231	06789
Ensembl ID		ENSG00000205581	ENSG00000100784
Uniprot IDs		P05114 Q6NSG7	O75582
PDB IDs			1VZO 3KN5 3KN6 7UP4 7UP5 7UP6 7UP7 7UP8
Enriched GO Terms of Interacting Partners?		TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Protein Serine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Protein Domain Specific Binding Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Gamma Radiation Regulation Of RNA Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Gene Expression Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Response To Lithium Ion Chromatin Organization Histone H3S28 Kinase Activity Response To Hormone Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Radiation Chromosome, Telomeric Region Nucleus Negative Regulation Of Biosynthetic Process Protein Kinase Activity Protein Modification Process Protein Phosphorylation	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Chromatin Organization DNA Binding Response To Light Stimulus Protein Heterodimerization Activity Response To UV Response To UV-B Nucleosome Assembly Nucleus Chromatin Remodeling Protein-containing Complex Assembly Chromatin DNA Binding Protein-containing Complex Organization Protein-DNA Complex Assembly Regulation Of Cell Development Response To Radiation Chromatin Cellular Response To UV Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Cellular Response To UV-B Regulation Of Cell Differentiation Transcription Regulator Complex Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Nucleoplasm Double-stranded DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Chromosome Cellular Component Assembly Chromatin Binding Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Regulation Of Myeloid Cell Differentiation Transcription Coactivator Binding Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Intracellular Signal Transduction
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