HMGN1 and RPS6KA4

Number of citations of the paper that reports this interaction (PubMedID 11438671)
62

Data Source:
HPRD (in vitro, in vivo)

		HMGN1	RPS6KA4
Description		high mobility group nucleosome binding domain 1	ribosomal protein S6 kinase A4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway
Pathways			Recycling pathway of L1
Drugs			Flavin mononucleotide
Diseases
GWAS		LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 33730874) Smoking status (ever vs never smokers) ( 30643258)	Cervical high-risk human papilloma virus infection ( 33225922) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Offspring birth weight ( 31043758) Primary biliary cholangitis ( 21399635) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Serum uric acid levels ( 32514006)
Interacting Genes		22 interacting genes: CDC42 CEBPA CHEK2 EP300 GSK3A HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	9 interacting genes: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4
Entrez ID		3150	8986
HPRD ID		01231	04677
Ensembl ID		ENSG00000205581	ENSG00000162302
Uniprot IDs		P05114 Q6NSG7	A0PJF8 B4DPV1 E9PJN1 O75676
PDB IDs
Enriched GO Terms of Interacting Partners?		TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Protein Serine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Protein Domain Specific Binding Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Gamma Radiation Regulation Of RNA Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Gene Expression Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Response To Lithium Ion Chromatin Organization Histone H3S28 Kinase Activity Response To Hormone Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Radiation Chromosome, Telomeric Region Nucleus Negative Regulation Of Biosynthetic Process Protein Kinase Activity Protein Modification Process Protein Phosphorylation	Regulation Of Golgi Inheritance Intracellular Signaling Cassette Regulation Of Transcription By RNA Polymerase II Trachea Formation Response To Growth Factor Intracellular Signal Transduction ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MAP Kinase Activity Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Nucleobase-containing Compound Metabolic Process Response To Peptide Response To Cytokine Regulation Of Intracellular Transport Cellular Response To Tumor Necrosis Factor Face Development Animal Organ Formation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Biosynthetic Process Response To Tumor Necrosis Factor Response To Light Stimulus Enzyme-linked Receptor Protein Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Interleukin-34-mediated Signaling Pathway Response To Purine-containing Compound Regulation Of Stress-activated MAPK Cascade Myeloid Leukocyte Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Lipid ATF4-CREB1 Transcription Factor Complex DNA-templated Transcription Regulation Of Gene Expression Osteoclast Differentiation Response To Radiation
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