HIP1 and CLTC

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		HIP1	CLTC
Gene Name		huntingtin interacting protein 1	clathrin, heavy chain (Hc)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Clathrin Binding Protein Binding, Bridging Phosphatidylinositol Binding	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Cytoskeleton Organization Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Apoptotic Signaling Pathway	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Alcoholism (12-month weekly alcohol consumption) ( 21529783)
Protein-Protein Interactions		22 interactors: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CLTA CLTB CLTC DAZAP2 EIF6 FBXO25 HIP1R HTT IFT57 ITSN1 MAPK6 NECAP1 PFDN1 REL RPS10 TFAP2A	60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		3092	1213
HPRD ID		03461	00350
Ensembl ID		ENSG00000127946	ENSG00000141367
Uniprot IDs		B4DK46 O00291	Q00610
PDB IDs		2NO2 2QA7 3I00	2XZG 4G55
Enriched GO Terms of Interacting Partners?		Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Zymogen Activation Neurotrophin Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Endopeptidase Activity Regulation Of Neuron Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Morphogenesis Of Embryonic Epithelium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of ERBB Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Nervous System Development Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle-mediated Transport Anatomical Structure Morphogenesis Protein Processing Regulation Of Neuron Apoptotic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Hyaluronan Biosynthetic Process Intracellular Transport Establishment Of Localization In Cell Regulation Of Cell Death Neural Tube Formation Positive Regulation Of Proteolysis Embryonic Epithelial Tube Formation Epithelial Tube Formation Intracellular Protein Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Glial Cell Apoptotic Process Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process ERBB Signaling Pathway Cellular Localization Tube Formation Protein Transport Programmed Cell Death	Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis
Tagcloud ?		128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Difference) ?		128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Intersection) ?