HIP1 and PFDN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HIP1	PFDN1
Gene Name		huntingtin interacting protein 1	prefoldin subunit 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle	Prefoldin Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Clathrin Binding Protein Binding, Bridging Phosphatidylinositol Binding	Sequence-specific DNA Binding Transcription Factor Activity Unfolded Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Cytoskeleton Organization Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Apoptotic Signaling Pathway	Regulation Of Transcription, DNA-templated Protein Folding Cell Cycle Telencephalon Development Cerebellum Development Actin Cytoskeleton Organization B Cell Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding
Pathways			Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding
Drugs
Diseases
GWAS		Alcoholism (12-month weekly alcohol consumption) ( 21529783)
Protein-Protein Interactions		22 interactors: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CLTA CLTB CLTC DAZAP2 EIF6 FBXO25 HIP1R HTT IFT57 ITSN1 MAPK6 NECAP1 PFDN1 REL RPS10 TFAP2A	54 interactors: ACTA1 ACTB ALB ASNA1 BRK1 CCDC85A CHGA DCTN1 DEFA1 DGCR14 EDRF1 EIF3C EIF4A2 EOMES EXT2 EZH2 FAM20C GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 KIAA1377 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 TUBA1A YEATS4 ZNF235
Entrez ID		3092	5201
HPRD ID		03461	05357
Ensembl ID		ENSG00000127946	ENSG00000113068
Uniprot IDs		B4DK46 O00291	O60925
PDB IDs		2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?		Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Zymogen Activation Neurotrophin Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Endopeptidase Activity Regulation Of Neuron Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Morphogenesis Of Embryonic Epithelium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of ERBB Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Nervous System Development Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle-mediated Transport Anatomical Structure Morphogenesis Protein Processing Regulation Of Neuron Apoptotic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Hyaluronan Biosynthetic Process Intracellular Transport Establishment Of Localization In Cell Regulation Of Cell Death Neural Tube Formation Positive Regulation Of Proteolysis Embryonic Epithelial Tube Formation Epithelial Tube Formation Intracellular Protein Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Glial Cell Apoptotic Process Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process ERBB Signaling Pathway Cellular Localization Tube Formation Protein Transport Programmed Cell Death	Organelle Organization Cellular Localization Cellular Macromolecule Biosynthetic Process Cellular Component Assembly Macromolecule Biosynthetic Process Gene Expression Membrane Organization RNA Biosynthetic Process Cellular Protein Localization Establishment Of Protein Localization To Membrane Protein Localization Developmental Process Cerebral Cortex Regionalization Mitotic Cell Cycle Biosynthetic Process Cellular Process Cytoskeleton-dependent Intracellular Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Metabolic Process Establishment Of Localization In Cell Anatomical Structure Development RNA Metabolic Process Organelle Localization 'de Novo' Posttranslational Protein Folding Intracellular Transport Cell Cycle Process 'de Novo' Protein Folding Regulation Of Metabolic Process Telencephalon Regionalization Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Protein Localization To Organelle Positive Regulation Of Cellular Metabolic Process Protein Localization To Membrane Vesicle Localization Regulation Of Cilium Assembly Multicellular Organismal Development Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Phase Transition Anatomical Structure Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Killing Of Cells Of Other Organism Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Anatomical Structure Formation Involved In Morphogenesis
Tagcloud ?		128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable
Tagcloud (Difference) ?		128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable
Tagcloud (Intersection) ?