HIP1 and CYRIB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HIP1	CYRIB
Description		huntingtin interacting protein 1	CYFIP related Rac1 interactor B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Endomembrane System Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Synapse Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Extracellular Region Mitochondrion Cilium Membrane Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Actin Binding Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Small GTPase Binding
	Biological Process	Endocytosis Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Migration Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Activation Regulation Of Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Molecule Of Bacterial Origin Regulation Of Mitochondrial Fission Regulation Of Establishment Of Cell Polarity Positive Regulation Of Memory T Cell Activation
Pathways		Clathrin-mediated endocytosis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Platelet degranulation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28448500 28892062 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A UBC	3 interacting genes: HIP1 MAPK6 NIF3L1
Entrez ID		3092	51571
HPRD ID		03461	13313
Ensembl ID		ENSG00000127946	ENSG00000153310
Uniprot IDs		B4DK46 O00291	A0A8V8TMP7 Q9NUQ9
PDB IDs		2NO2 2QA7 3I00	7AJK
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin Coat Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Endolysosome Membrane Receptor-mediated Endocytosis Clathrin Coat Assembly Response To Anesthetic Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin Vesicle Coat Response To Cobalt Ion Endocytosis Presynaptic Endocytic Zone Membrane Clathrin Adaptor Activity Apoptosome Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Hyaluronan Biosynthetic Process Protein-containing Complex Import Into Cell Tube Closure Glial Cell Apoptotic Process Cytoplasmic Vesicle Regulation Of Hyaluronan Biosynthetic Process Death-inducing Signaling Complex Clathrin Light Chain Binding Cytosol Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Clathrin Complex Protein Binding Intracellular Transport Positive Regulation Of Pyroptotic Inflammatory Response Tube Formation Clathrin Heavy Chain Binding AP-2 Adaptor Complex Fibroblast Apoptotic Process Establishment Of Localization In Cell Cytoplasm Clathrin Adaptor Complex Cysteine-type Endopeptidase Activity Protein Kinase Binding Clathrin-coated Endocytic Vesicle Membrane Kidney Development Receptor Internalization	Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Glutamate Receptor Binding Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Heterodimerization Activity Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin Light Chain Binding Septin Cytoskeleton AP-2 Adaptor Complex Binding Neurotransmitter Receptor Transport MAP Kinase Activity
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