HIP1 and NECAP1

Number of citations of the paper that reports this interaction (PMID 17762867)
8

Data Source:
HPRD (in vivo)

		HIP1	NECAP1
Gene Name		huntingtin interacting protein 1	NECAP endocytosis associated 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Coated Pit Clathrin Vesicle Coat
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Clathrin Binding Protein Binding, Bridging Phosphatidylinositol Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Cytoskeleton Organization Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Apoptotic Signaling Pathway	Endocytosis Protein Transport
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Alcoholism (12-month weekly alcohol consumption) ( 21529783)
Protein-Protein Interactions		22 interactors: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CLTA CLTB CLTC DAZAP2 EIF6 FBXO25 HIP1R HTT IFT57 ITSN1 MAPK6 NECAP1 PFDN1 REL RPS10 TFAP2A	6 interactors: AMPH APP DAB2 HIP1 REL SNAP91
Entrez ID		3092	25977
HPRD ID		03461	14819
Ensembl ID		ENSG00000127946	ENSG00000089818
Uniprot IDs		B4DK46 O00291	Q8NC96
PDB IDs		2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?		Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Zymogen Activation Neurotrophin Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Endopeptidase Activity Regulation Of Neuron Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Morphogenesis Of Embryonic Epithelium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of ERBB Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Nervous System Development Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle-mediated Transport Anatomical Structure Morphogenesis Protein Processing Regulation Of Neuron Apoptotic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Hyaluronan Biosynthetic Process Intracellular Transport Establishment Of Localization In Cell Regulation Of Cell Death Neural Tube Formation Positive Regulation Of Proteolysis Embryonic Epithelial Tube Formation Epithelial Tube Formation Intracellular Protein Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Glial Cell Apoptotic Process Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process ERBB Signaling Pathway Cellular Localization Tube Formation Protein Transport Programmed Cell Death	Clathrin Coat Assembly Membrane Budding Regulation Of Clathrin-mediated Endocytosis Vesicle-mediated Transport Endocytosis Regulation Of Endocytosis Vesicle Organization Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Proteolysis Cellular Protein Complex Assembly Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Positive Regulation Of Endocytosis Cellular Macromolecular Complex Assembly Regulation Of Proteolysis Leading Edge Cell Differentiation Synaptic Growth At Neuromuscular Junction Learning Cellular Component Assembly Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Positive Regulation Of Clathrin-mediated Endocytosis Membrane Organization Regulation Of Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Early Endosome To Late Endosome Transport Apoptotic Process Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Axon Choice Point Recognition Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Learning Or Memory Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Transport Cognition Neuron Remodeling Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport
Tagcloud ?		128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable
Tagcloud (Difference) ?		128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable
Tagcloud (Intersection) ?