HIP1 and NECAP1

Number of citations of the paper that reports this interaction (PubMedID 17762867)
67

Data Source:
HPRD (in vivo)

		HIP1	NECAP1
Description		huntingtin interacting protein 1	NECAP endocytosis associated 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Endomembrane System Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Synapse Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Presynapse
	Molecular Function	Actin Binding Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding
	Biological Process	Endocytosis Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Endocytosis Protein Transport Vesicle-mediated Transport Presynaptic Endocytosis
Pathways		Clathrin-mediated endocytosis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28448500 28892062 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A UBC	10 interacting genes: AMPH AP1B1 APP DAB2 DAPK1 DNAJC5 HIP1 REL SNAP91 SNCA
Entrez ID		3092	25977
HPRD ID		03461	14819
Ensembl ID		ENSG00000127946	ENSG00000089818
Uniprot IDs		B4DK46 O00291	Q8NC96
PDB IDs		2NO2 2QA7 3I00	6RH5 6RH6
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin Coat Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Endolysosome Membrane Receptor-mediated Endocytosis Clathrin Coat Assembly Response To Anesthetic Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin Vesicle Coat Response To Cobalt Ion Endocytosis Presynaptic Endocytic Zone Membrane Clathrin Adaptor Activity Apoptosome Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Hyaluronan Biosynthetic Process Protein-containing Complex Import Into Cell Tube Closure Glial Cell Apoptotic Process Cytoplasmic Vesicle Regulation Of Hyaluronan Biosynthetic Process Death-inducing Signaling Complex Clathrin Light Chain Binding Cytosol Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Clathrin Complex Protein Binding Intracellular Transport Positive Regulation Of Pyroptotic Inflammatory Response Tube Formation Clathrin Heavy Chain Binding AP-2 Adaptor Complex Fibroblast Apoptotic Process Establishment Of Localization In Cell Cytoplasm Clathrin Adaptor Complex Cysteine-type Endopeptidase Activity Protein Kinase Binding Clathrin-coated Endocytic Vesicle Membrane Kidney Development Receptor Internalization	Synaptic Vesicle Vesicle-mediated Transport Endocytosis Regulation Of Vesicle-mediated Transport Clathrin Coat Assembly Phospholipid Binding Import Into Cell Regulation Of Receptor-mediated Endocytosis Regulation Of Endocytosis Clathrin Binding Clathrin-coated Vesicle Membrane Positive Regulation Of Endocytosis Cytoplasmic Vesicle Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Programmed Cell Death Cell Death Regulation Of Transport Presynapse Clathrin-coated Pit Clathrin-coated Vesicle Vesicle-mediated Transport In Synapse Clathrin Adaptor Activity Regulation Of Clathrin-dependent Endocytosis Regulation Of Apoptotic Process Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Regulation Of Programmed Cell Death Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Positive Regulation Of Small Molecule Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Response To Copper Ion Response To Cytokine Positive Regulation Of Catabolic Process Response To Peptide Synaptic Vesicle Endocytosis Postsynapse Presynaptic Endocytosis Regulation Of Neuron Apoptotic Process Protein-containing Complex Assembly Actin Cytoskeleton
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