HIP1 and APAF1

Number of citations of the paper that reports this interaction (PMID 16979168)
4

Data Source:
HPRD (in vivo, in vitro)

		HIP1	APAF1
Gene Name		huntingtin interacting protein 1	apoptotic peptidase activating factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytosol Apoptosome Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Clathrin Binding Protein Binding, Bridging Phosphatidylinositol Binding	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding ADP Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Cytoskeleton Organization Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Apoptotic Signaling Pathway	Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Apoptotic factor-mediated response Programmed Cell Death Cytochrome c-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs			Adenosine triphosphate Adenosine-5\'-Diphosphate
Diseases
GWAS		Alcoholism (12-month weekly alcohol consumption) ( 21529783)
Protein-Protein Interactions		22 interactors: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CLTA CLTB CLTC DAZAP2 EIF6 FBXO25 HIP1R HTT IFT57 ITSN1 MAPK6 NECAP1 PFDN1 REL RPS10 TFAP2A	18 interactors: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1
Entrez ID		3092	317
HPRD ID		03461	03755
Ensembl ID		ENSG00000127946	ENSG00000120868
Uniprot IDs		B4DK46 O00291	O14727
PDB IDs		2NO2 2QA7 3I00	1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3YGS
Enriched GO Terms of Interacting Partners?		Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Zymogen Activation Neurotrophin Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Endopeptidase Activity Regulation Of Neuron Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Morphogenesis Of Embryonic Epithelium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of ERBB Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Nervous System Development Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle-mediated Transport Anatomical Structure Morphogenesis Protein Processing Regulation Of Neuron Apoptotic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Hyaluronan Biosynthetic Process Intracellular Transport Establishment Of Localization In Cell Regulation Of Cell Death Neural Tube Formation Positive Regulation Of Proteolysis Embryonic Epithelial Tube Formation Epithelial Tube Formation Intracellular Protein Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Glial Cell Apoptotic Process Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process ERBB Signaling Pathway Cellular Localization Tube Formation Protein Transport Programmed Cell Death	Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Programmed Cell Death Protein Processing Positive Regulation Of Cell Death Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Neuron Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Death Negative Regulation Of Apoptotic Process Hepatocyte Apoptotic Process Regulation Of Catalytic Activity Execution Phase Of Apoptosis Positive Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress
Tagcloud ?		128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Difference) ?		128a biomarker brains candidates canonical causal disruption dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Intersection) ?		downregulated