CLN3 and KCNIP3

Number of citations of the paper that reports this interaction (PMID 17189291)
8

Data Source:
BioGRID (two hybrid)

		CLN3	KCNIP3
Gene Name		ceroid-lipofuscinosis, neuronal 3	Kv channel interacting protein 3, calsenilin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Early Endosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Plasma Membrane Caveola Synaptic Vesicle Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Neuron Projection Membrane Raft	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	Protein Binding Unfolded Protein Binding	DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein C-terminus Binding Potassium Channel Regulator Activity Sequence-specific DNA Binding Ion Channel Binding Calcium-dependent Protein Binding
	Biological Process	Autophagic Vacuole Fusion Action Potential Globoside Metabolic Process Cellular Amino Acid Metabolic Process Ceramide Metabolic Process Glucosylceramide Metabolic Process Galactosylceramide Metabolic Process Sphingomyelin Metabolic Process Receptor-mediated Endocytosis Vacuolar Transport Lysosome Organization Lysosomal Lumen Acidification Associative Learning Arginine Transport Macroautophagy Negative Regulation Of Macroautophagy Protein Processing Protein Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway Lysosomal Lumen PH Elevation Neurotransmitter Metabolic Process Amyloid Precursor Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteolysis Vesicle Transport Along Microtubule Neuromuscular Process Controlling Balance Cytosolic Calcium Ion Homeostasis Membrane Organization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Protein Transport Apoptotic Process Signal Transduction Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Regulation Of Neuron Apoptotic Process Behavioral Response To Pain Potassium Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		2 interactors: KCNIP3 SBDS	17 interactors: ADRBK1 CALM2 CASP3 CD177 CLN3 CREB1 CREM GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2
Entrez ID		1201	30818
HPRD ID		08450	05232
Ensembl ID		ENSG00000188603	ENSG00000115041
Uniprot IDs		B4DFF3 Q13286	Q9Y2W7
PDB IDs			2E6W
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Stabilization Spindle Stabilization Bone Marrow Development Mature Ribosome Assembly Regulation Of Mitotic Spindle Organization Behavioral Response To Pain Inner Cell Mass Cell Proliferation Ribosomal Large Subunit Biogenesis Blastocyst Growth Ribosome Assembly Negative Regulation Of Microtubule Depolymerization Response To Pain Negative Regulation Of Microtubule Polymerization Or Depolymerization Bone Mineralization	Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Negative Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Amyloid Precursor Protein Metabolic Process Regulation Of Protein Phosphorylation Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Phosphorylation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Negative Regulation Of Cellular Metabolic Process Cell Communication Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Activation Of Phospholipase C Activity Negative Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Phospholipase C Activity Regulation Of Kinase Activity Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Response To Stress Negative Regulation Of Kinase Activity Protein Processing Negative Regulation Of Apoptotic Process Positive Regulation Of Phospholipase Activity Negative Regulation Of Programmed Cell Death Learning Or Memory
Tagcloud ?		associates breakdown cerevisiae chaperone cln2 close defect degradation degraded dnaj folding g1 h1 homolog inactivation nonpermissive p34cdc28 phosphorylation proper proteasome proximity pure reconstitution saccharomyces seems segment sis1 triggered ydj1
Tagcloud (Difference) ?		associates breakdown cerevisiae chaperone cln2 close defect degradation degraded dnaj folding g1 h1 homolog inactivation nonpermissive p34cdc28 phosphorylation proper proteasome proximity pure reconstitution saccharomyces seems segment sis1 triggered ydj1
Tagcloud (Intersection) ?