CLN3

Gene Name		ceroid-lipofuscinosis, neuronal 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Early Endosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Plasma Membrane Caveola Synaptic Vesicle Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Neuron Projection Membrane Raft
	Molecular Function	Protein Binding Unfolded Protein Binding
	Biological Process	Autophagic Vacuole Fusion Action Potential Globoside Metabolic Process Cellular Amino Acid Metabolic Process Ceramide Metabolic Process Glucosylceramide Metabolic Process Galactosylceramide Metabolic Process Sphingomyelin Metabolic Process Receptor-mediated Endocytosis Vacuolar Transport Lysosome Organization Lysosomal Lumen Acidification Associative Learning Arginine Transport Macroautophagy Negative Regulation Of Macroautophagy Protein Processing Protein Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway Lysosomal Lumen PH Elevation Neurotransmitter Metabolic Process Amyloid Precursor Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteolysis Vesicle Transport Along Microtubule Neuromuscular Process Controlling Balance Cytosolic Calcium Ion Homeostasis Membrane Organization
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease (early onset) ( 19915574)
Protein-protein Interactions		2 interactors: KCNIP3 SBDS
Entrez ID		1201
HPRD ID		08450
Ensembl ID		ENSG00000188603
Uniprot IDs		B4DFF3 Q13286
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Stabilization Spindle Stabilization Bone Marrow Development Mature Ribosome Assembly Regulation Of Mitotic Spindle Organization Behavioral Response To Pain Inner Cell Mass Cell Proliferation Ribosomal Large Subunit Biogenesis Blastocyst Growth Ribosome Assembly Negative Regulation Of Microtubule Depolymerization Response To Pain Negative Regulation Of Microtubule Polymerization Or Depolymerization Bone Mineralization
Tagcloud ?		associates breakdown cerevisiae chaperone cln2 close defect degradation degraded dnaj folding g1 h1 homolog inactivation nonpermissive p34cdc28 phosphorylation proper proteasome proximity pure reconstitution saccharomyces seems segment sis1 triggered ydj1