NBN and DCLRE1C

Number of citations of the paper that reports this interaction (PMID 15456891)
38

Data Source:
HPRD (in vivo, in vitro)

		NBN	DCLRE1C
Gene Name		nibrin	DNA cross-link repair 1C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body	Nucleus
	Molecular Function	Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding Transcription Factor Binding Protein N-terminus Binding	Single-stranded DNA Endodeoxyribonuclease Activity 5'-3' Exonuclease Activity
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Blastocyst Growth DNA Repair Double-strand Break Repair Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Cell Proliferation Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Intrinsic Apoptotic Signaling Pathway	Telomere Maintenance DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Response To Ionizing Radiation B Cell Differentiation V(D)J Recombination Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		ATM mediated phosphorylation of repair proteins Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci ATM mediated response to DNA double-strand break Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ATF2 ATM ATR BRCA1 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AFX MDC1 MRE11A NCL PRKDC RAD18 RAD50 RECQL5 RNF8 SIRT1 TERF1 TLK1 TREX1 UBE2D1 UBE2N XRCC4 XRCC5	11 interactors: ATM ATR BRCA1 DDB1 DDB2 MRE11A NBN PRKDC PSMD9 RAD50 TP53BP1
Entrez ID		4683	64421
HPRD ID		04050	05817
Ensembl ID		ENSG00000104320	ENSG00000152457
Uniprot IDs		O60934	B3KMX5 Q96SD1
PDB IDs			3W1B 3W1G 4HTP
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Recombination Response To Ionizing Radiation Response To Stress Cell Cycle Process Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Response To Radiation Cell Cycle Checkpoint Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Damage Checkpoint DNA Replication Telomere Maintenance Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus Cellular Response To Stimulus Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Organelle Organization Response To Stimulus Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of DNA Repair Negative Regulation Of Mitotic Cell Cycle Intra-S DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Repair Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of DNA Replication Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress DNA Damage Checkpoint DNA Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Stress G2 DNA Damage Checkpoint Cell Cycle Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Mitotic G2 DNA Damage Checkpoint Chromosome Organization Nitrogen Compound Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of Protein Autophosphorylation Regulation Of Cellular Protein Metabolic Process Response To Ionizing Radiation DNA Catabolic Process Cellular Response To Radiation Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Heterocycle Metabolic Process Reciprocal Meiotic Recombination Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Response To Gamma Radiation Meiotic Cell Cycle Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Tagcloud ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	alleles breakpoints carrier casp3 catabolism cdh19 centered cnv cnvs cyp2c19 cyp450 dab2ip deletion differed disrupted disturbed encodes estradiol exact finnish inherited itga9 multiplex nested northern participating qpcr singletons unselected
Tagcloud (Difference) ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	alleles breakpoints carrier casp3 catabolism cdh19 centered cnv cnvs cyp2c19 cyp450 dab2ip deletion differed disrupted disturbed encodes estradiol exact finnish inherited itga9 multiplex nested northern participating qpcr singletons unselected
Tagcloud (Intersection) ?