NBN and VRK1

Number of citations of the paper that reports this interaction (PubMedID 26869104)
0

Data Source:
BioGRID (enzymatic study)

		NBN	VRK1
Description		nibrin	VRK serine/threonine kinase 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Golgi Apparatus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body BRCA1-C Complex Chromosomal Region	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Cytosol Cajal Body
	Molecular Function	Damaged DNA Binding Protein Binding Histone Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding DNA-binding Transcription Factor Binding Chromatin-protein Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nucleosomal DNA Binding Histone H3S10 Kinase Activity Histone Binding Histone H3T3 Kinase Activity Protein Serine Kinase Activity Histone H2AX Kinase Activity
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing In Utero Embryonic Development Blastocyst Growth DNA Repair Double-strand Break Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neuroblast Proliferation Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Telomere Maintenance In Response To DNA Damage Mitotic G2/M Transition Checkpoint Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Regulation Of Cell Cycle R-loop Processing Protein K63-linked Ubiquitination T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair	Chromatin Remodeling Protein Phosphorylation DNA Damage Response Mitotic Nuclear Membrane Disassembly Signal Transduction Cajal Body Organization Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cell Division Golgi Disassembly Positive Regulation Of Protein Localization To Chromatin Regulation Of Neuron Migration
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	Pontocerebellar hypoplasia
GWAS		Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494)	Bone ultrasound measurement (velocity of sound) ( 28472463) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive function ( 24684796) Copper levels ( 26025379) Fractures (paediatric) ( 32742401) Metabolite levels ( 23823483) Neutrophil count ( 21507922) Night sleep phenotypes ( 27126917) Staphylococcus aureus infection ( 24847357)
Interacting Genes		35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NABP2 NAT2 NCL PRKDC RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5	9 interacting genes: H2BC21 H3C14 HIF1A NBN OGT PLK3 SRPK2 TP53 VHL
Entrez ID		4683	7443
HPRD ID		04050	03701
Ensembl ID		ENSG00000104320	ENSG00000100749
Uniprot IDs		A0A0C4DG07 O60934	A0A7P0T838 A0A7P0TB08 H0YJF7 Q99986
PDB IDs		5WQD 7SID 8BAH	2KTY 2KUL 2LAV 2RSV 3OP5 5UKF 5UVF 6AC9 6BP0 6BRU 6BTW 6BU6 6CFM 6CMM 6CNX 6CQH 6CSW 6DD4 6NPN 6VXU 6VZH 7M10 7TAN 8F8Y 8V42
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Metabolic Process DNA Repair Double-strand Break Repair Response To Ionizing Radiation Nucleoplasm Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Recombination Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Response To Radiation Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Recombinational Repair Regulation Of Double-strand Break Repair Telomere Maintenance Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Telomere Organization Chromosome Nucleobase-containing Compound Metabolic Process Chromatin Organization Double-strand Break Repair Via Homologous Recombination Response To Gamma Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Site Of Double-strand Break Cellular Response To Ionizing Radiation Positive Regulation Of DNA Repair Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Organization Involved In Meiotic Cell Cycle Chromatin Remodeling Cellular Response To Gamma Radiation Positive Regulation Of Double-strand Break Repair DNA Binding Regulation Of Primary Metabolic Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleoplasm Neuroblast Proliferation Chromatin Organization Regulation Of Carbohydrate Catabolic Process P53 Binding Response To Stress Regulation Of Purine Nucleotide Metabolic Process Chromatin Remodeling R-loop Processing Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Precursor Cell Proliferation Signal Transduction By P53 Class Mediator Regulation Of Thymocyte Apoptotic Process Protein Heterodimerization Activity Negative Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Autophagy Mitotic G1/S Transition Checkpoint Signaling Lactate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Hypoxia Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Regulation Of TOR Signaling Cellular Response To Oxygen Levels Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Intracellular Signal Transduction Replication Fork 14-3-3 Protein Binding Nucleus Negative Regulation Of Mitotic Cell Cycle Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Phase Transition Regulation Of T Cell Apoptotic Process Protein-containing Complex Assembly Regulation Of Neuroblast Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Chromosome Regulation Of Primary Metabolic Process
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