NBN and CDK9

Number of citations of the paper that reports this interaction (PMID 8170997)
45

Data Source:
HPRD (in vitro, in vivo)

		NBN	CDK9
Gene Name		nibrin	cyclin-dependent kinase 9
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Positive Transcription Elongation Factor Complex B Membrane PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding Transcription Factor Binding Protein N-terminus Binding	DNA Binding Chromatin Binding Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity SnRNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Blastocyst Growth DNA Repair Double-strand Break Repair Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Cell Proliferation Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Intrinsic Apoptotic Signaling Pathway	DNA Repair Regulation Of DNA Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cell Proliferation Gene Expression Viral Process Regulation Of Histone Modification Replication Fork Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus
Pathways		ATM mediated phosphorylation of repair proteins Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci ATM mediated response to DNA double-strand break Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair	Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ATF2 ATM ATR BRCA1 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AFX MDC1 MRE11A NCL PRKDC RAD18 RAD50 RECQL5 RNF8 SIRT1 TERF1 TLK1 TREX1 UBE2D1 UBE2N XRCC4 XRCC5	56 interactors: ACTL6A AFF4 AR BCL10 BRCA1 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CTD CTDP1 CTDSPL CUL1 DHX30 FBXO25 GRN GTF2F1 HEXIM1 HEXIM2 HIST2H2BE HLTF HSPA1A HTATSF1 IL6ST MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6
Entrez ID		4683	1025
HPRD ID		04050	16016
Ensembl ID		ENSG00000104320	ENSG00000136807
Uniprot IDs		O60934	P50750
PDB IDs			1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Recombination Response To Ionizing Radiation Response To Stress Cell Cycle Process Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Response To Radiation Cell Cycle Checkpoint Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Damage Checkpoint DNA Replication Telomere Maintenance Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus Cellular Response To Stimulus Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Organelle Organization Response To Stimulus Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of DNA Repair Negative Regulation Of Mitotic Cell Cycle Intra-S DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Repair Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of DNA Replication Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process	Positive Regulation Of Cellular Metabolic Process Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Phosphorylation Regulation Of Protein Phosphorylation DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Biosynthetic Process Regulation Of Viral Transcription Cell Cycle Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Stimulus Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle
Tagcloud ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Difference) ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Intersection) ?