NME7 and MAP4K4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NME7	MAP4K4
Description		NME/NM23 family member 7	mitogen-activated protein kinase kinase kinase kinase 4
Image
GO Annotations	Cellular Component	Gamma-tubulin Ring Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Cytoplasm Focal Adhesion
	Molecular Function	Nucleoside Diphosphate Kinase Activity Protein Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Hydrolase Activity	Nucleotide Binding Creatine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Determination Of Left/right Symmetry Brain Development Regulation Of Microtubule Nucleation Flagellated Sperm Motility Intraciliary Transport Receptor Clustering Cilium Assembly Left/right Pattern Formation Cellular Response To Leukemia Inhibitory Factor	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Intracellular Signal Transduction
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Oxidative Stress Induced Senescence
Drugs			Fostamatinib
Diseases
GWAS		Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left-handedness ( 32989287) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568 30659681 33592630)	Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)
Interacting Genes		74 interacting genes: AMOTL2 ARHGAP9 BTBD6 CARD10 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC42EP2 CEP72 DDIT4L DDX1 DISC1 DNAI7 EFHC2 FKBP6 FLOT1 FOSL1 FOSL2 GATAD2B GLIS2 GOLGA2 GSC2 HAUS8 IKZF1 IKZF3 INCA1 ISY1-RAB43 KRT18 KRT75 LNX1 MAP4K4 MED11 MED30 MEI4 MEOX2 MYOT NAB2 NEFL NFKBIL1 NIF3L1 NME4 NT5C2 OFD1 PAX4 PIAS2 PICK1 POU6F2 PROSER3 PSMA1 REL RUBCN SHTN1 SNAPIN SNX32 SYCE1 TCF4 TCHP TEKT1 TEPSIN THAP10 TNIP1 TNNI2 TRIM27 TRIM48 TUFT1 YWHAQ ZBTB48 ZNF23 ZNF263 ZNF343 ZNF526 ZNF620	27 interacting genes: BRCA1 CASP8 CTTNBP2NL DOK1 DSCAM GBP3 H2BC21 ITGB1 KIF26B KIF5A LATS1 MAP3K7 MOB4 NCK1 NME7 PPP1CA PPP1CC PPP2CA PRKCE PTK2B RAP2A RASA1 RIPPLY3 SLC9A1 STRIP1 STRN4 TBPL2
Entrez ID		29922	9448
HPRD ID		11394	05235
Ensembl ID		ENSG00000143156	ENSG00000071054
Uniprot IDs		Q9Y5B8	B7Z3V5 E7EN19 G5E948 O95819 V9HWH3
PDB IDs		7UNG 8J07	4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q 8V5I
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity Regulation Of RNA Metabolic Process Phosphatidylinositol 3-kinase Inhibitor Activity	FAR/SIN/STRIPAK Complex Regulation Of Hippo Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Hippo Signaling Regulation Of Supramolecular Fiber Organization Cytoplasm Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Filament Length Regulation Of Cellular Component Size RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Lamellipodium Protein Dephosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Glutamatergic Synapse Protein-macromolecule Adaptor Activity Regulation Of Actin Filament-based Process Postsynapse Positive Regulation Of Locomotion Negative Regulation Of Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Cell Communication Regulation Of Organelle Organization Negative Regulation Of Signaling Dephosphorylation PTW/PP1 Phosphatase Complex Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Signaling Receptor Activator Activity Dendritic Spine Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Synapse Organization Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cellular Component Biogenesis Gamma-tubulin Ring Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Positive Regulation Of Programmed Cell Death
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