NME7 and DNAI7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NME7	DNAI7
Description		NME/NM23 family member 7	dynein axonemal intermediate chain 7
Image
GO Annotations	Cellular Component	Gamma-tubulin Ring Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Cytoplasm Axonemal Dynein Complex Cilium Axoneme Cell Projection
	Molecular Function	Nucleoside Diphosphate Kinase Activity Protein Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Hydrolase Activity	Protein Binding Microtubule Binding Beta-tubulin Binding
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Determination Of Left/right Symmetry Brain Development Regulation Of Microtubule Nucleation Flagellated Sperm Motility Intraciliary Transport Receptor Clustering Cilium Assembly Left/right Pattern Formation Cellular Response To Leukemia Inhibitory Factor
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left-handedness ( 32989287) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568 30659681 33592630)
Interacting Genes		74 interacting genes: AMOTL2 ARHGAP9 BTBD6 CARD10 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC42EP2 CEP72 DDIT4L DDX1 DISC1 DNAI7 EFHC2 FKBP6 FLOT1 FOSL1 FOSL2 GATAD2B GLIS2 GOLGA2 GSC2 HAUS8 IKZF1 IKZF3 INCA1 ISY1-RAB43 KRT18 KRT75 LNX1 MAP4K4 MED11 MED30 MEI4 MEOX2 MYOT NAB2 NEFL NFKBIL1 NIF3L1 NME4 NT5C2 OFD1 PAX4 PIAS2 PICK1 POU6F2 PROSER3 PSMA1 REL RUBCN SHTN1 SNAPIN SNX32 SYCE1 TCF4 TCHP TEKT1 TEPSIN THAP10 TNIP1 TNNI2 TRIM27 TRIM48 TUFT1 YWHAQ ZBTB48 ZNF23 ZNF263 ZNF343 ZNF526 ZNF620	4 interacting genes: ABI2 BARD1 ITSN1 NME7
Entrez ID		29922	55259
HPRD ID		11394	16684
Ensembl ID		ENSG00000143156	ENSG00000118307
Uniprot IDs		Q9Y5B8	B4DY27 B4E376 Q6TDU7
PDB IDs		7UNG 8J07	8J07
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity Regulation Of RNA Metabolic Process Phosphatidylinositol 3-kinase Inhibitor Activity	Histone H2AK127 Ubiquitin Ligase Activity Kinase Binding Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Regulation Of Postsynapse Organization Dendritic Spine Clathrin-dependent Synaptic Vesicle Endocytosis Zonula Adherens Assembly Lamellipodium BRCA1-A Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Postsynaptic Endocytic Zone Positive Regulation Of Caveolin-mediated Endocytosis Cell Projection Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Synapse Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Actin-based Cell Projection Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Regulation Of MRNA 3'-end Processing Postsynaptic Actin Cytoskeleton 3'-5'-DNA Exonuclease Activity Regulation Of Growth Hormone Secretion SCAR Complex Positive Regulation Of Actin Nucleation Regulation Of Supramolecular Fiber Organization CTP Metabolic Process CTP Biosynthetic Process Gamma-tubulin Ring Complex Left/right Pattern Formation DNA Strand Resection Involved In Replication Fork Processing Nucleoside Diphosphate Kinase Activity Regulation Of Modification Of Postsynaptic Structure Adherens Junction Assembly Apical Dendrite Filopodium Tip Intracellular Signal Transduction Proline-rich Region Binding Intracellular Vesicle Regulation Of Modification Of Synaptic Structure
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