NME7 and MED11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NME7	MED11
Description		NME/NM23 family member 7	mediator complex subunit 11
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GO Annotations	Cellular Component	Gamma-tubulin Ring Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Nucleoside Diphosphate Kinase Activity Protein Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Hydrolase Activity	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Determination Of Left/right Symmetry Brain Development Regulation Of Microtubule Nucleation Flagellated Sperm Motility Intraciliary Transport Receptor Clustering Cilium Assembly Left/right Pattern Formation Cellular Response To Leukemia Inhibitory Factor	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left-handedness ( 32989287) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568 30659681 33592630)
Interacting Genes		74 interacting genes: AMOTL2 ARHGAP9 BTBD6 CARD10 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC42EP2 CEP72 DDIT4L DDX1 DISC1 DNAI7 EFHC2 FKBP6 FLOT1 FOSL1 FOSL2 GATAD2B GLIS2 GOLGA2 GSC2 HAUS8 IKZF1 IKZF3 INCA1 ISY1-RAB43 KRT18 KRT75 LNX1 MAP4K4 MED11 MED30 MEI4 MEOX2 MYOT NAB2 NEFL NFKBIL1 NIF3L1 NME4 NT5C2 OFD1 PAX4 PIAS2 PICK1 POU6F2 PROSER3 PSMA1 REL RUBCN SHTN1 SNAPIN SNX32 SYCE1 TCF4 TCHP TEKT1 TEPSIN THAP10 TNIP1 TNNI2 TRIM27 TRIM48 TUFT1 YWHAQ ZBTB48 ZNF23 ZNF263 ZNF343 ZNF526 ZNF620	14 interacting genes: ABI2 APP CCDC120 CFTR GCSH MED22 MED8 MED9 NDEL1 NME7 SGF29 SSC5D SYCE2 USHBP1
Entrez ID		29922	400569
HPRD ID		11394	14709
Ensembl ID		ENSG00000143156	ENSG00000161920
Uniprot IDs		Q9Y5B8	I3L3E8 Q9P086
PDB IDs		7UNG 8J07	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity Regulation Of RNA Metabolic Process Phosphatidylinositol 3-kinase Inhibitor Activity	Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Transport Along Microtubule Protein-DNA Complex Assembly Cytoskeleton-dependent Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Microtubule-based Transport Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Gene Expression, Epigenetic Cellular Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Cell Projection Morphogenesis Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Endosome To Plasma Membrane Transport Vesicle Cellular Component Assembly Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport PDZ Domain Binding Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Aminomethyltransferase Activity
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