NME7 and NT5C2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		NME7	NT5C2
Description		NME/NM23 family member 7	5'-nucleotidase, cytosolic II
Image
GO Annotations	Cellular Component	Gamma-tubulin Ring Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Cytoplasm Cytosol
	Molecular Function	Nucleoside Diphosphate Kinase Activity Protein Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Hydrolase Activity	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding 5'-nucleotidase Activity Transferase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Nucleoside Phosphotransferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Determination Of Left/right Symmetry Brain Development Regulation Of Microtubule Nucleation Flagellated Sperm Motility Intraciliary Transport Receptor Clustering Cilium Assembly Left/right Pattern Formation Cellular Response To Leukemia Inhibitory Factor	Allantoin Metabolic Process GMP Catabolic Process To Guanine IMP Catabolic Process Nucleotide Metabolic Process Amide Catabolic Process GMP Metabolic Process GMP Catabolic Process IMP Metabolic Process DGMP Metabolic Process DGMP Catabolic Process Adenosine Metabolic Process Negative Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Antiviral Innate Immune Response
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Abacavir metabolism Purine catabolism Ribavirin ADME
Drugs			ATP Taribavirin
Diseases
GWAS		Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left-handedness ( 32989287) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568 30659681 33592630)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758 27680694) Blood pressure ( 21572416 21909110 24001895) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Coronary artery disease ( 24262325 26343387 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Diastolic blood pressure ( 30487518 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 32709000 31879980 30487518) Immature fraction of reticulocytes ( 32888494) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intracranial aneurysm ( 33199917) Mean arterial pressure ( 27618448 30487518 29403010 26390057) Mean corpuscular hemoglobin ( 32888494) Metabolically unhealthy in normal weight ( 33500527) Myocardial infarction ( 26343387) Pulse pressure ( 29403010 30578418 30487518 28739976) Red cell distribution width ( 27863252) Response to citalopram or escitalopram and depression ( 27622933) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 23894747 25056061 21926974 23974872 28991256 22688191 30285260 29483656) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 19430483 27618447 27618452 26390057 29403010 21909115 28135244 30487518 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) White matter lesion progression ( 26451028)
Interacting Genes		74 interacting genes: AMOTL2 ARHGAP9 BTBD6 CARD10 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC42EP2 CEP72 DDIT4L DDX1 DISC1 DNAI7 EFHC2 FKBP6 FLOT1 FOSL1 FOSL2 GATAD2B GLIS2 GOLGA2 GSC2 HAUS8 IKZF1 IKZF3 INCA1 ISY1-RAB43 KRT18 KRT75 LNX1 MAP4K4 MED11 MED30 MEI4 MEOX2 MYOT NAB2 NEFL NFKBIL1 NIF3L1 NME4 NT5C2 OFD1 PAX4 PIAS2 PICK1 POU6F2 PROSER3 PSMA1 REL RUBCN SHTN1 SNAPIN SNX32 SYCE1 TCF4 TCHP TEKT1 TEPSIN THAP10 TNIP1 TNNI2 TRIM27 TRIM48 TUFT1 YWHAQ ZBTB48 ZNF23 ZNF263 ZNF343 ZNF526 ZNF620	11 interacting genes: ATP5PO CALM1 FXR2 GLYCTK MOB1B MOB3B MOB3C NME7 NOC4L NUDT18 SDCBP
Entrez ID		29922	22978
HPRD ID		11394	02686
Ensembl ID		ENSG00000143156	ENSG00000076685
Uniprot IDs		Q9Y5B8	A0A384MED8 A0A6Q8PHP0 A8K6K2 P49902
PDB IDs		7UNG 8J07	2J2C 2JC9 2JCM 2XCV 2XCW 2XCX 2XJB 2XJC 2XJD 2XJE 2XJF 4H4B 5CQZ 5CR7 5K7Y 5L4Z 5L50 5OPK 5OPL 5OPM 5OPN 5OPO 5OPP 6DD3 6DDB 6DDC 6DDH 6DDK 6DDL 6DDO 6DDQ 6DDX 6DDY 6DDZ 6DE0 6DE1 6DE2 6DE3 6FIR 6FIS 6FIU 6FIW 6FXH
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity Regulation Of RNA Metabolic Process Phosphatidylinositol 3-kinase Inhibitor Activity	Protein Kinase Activator Activity Purine Ribonucleotide Metabolic Process Estradiol Binding Purine Nucleotide Metabolic Process Carbohydrate Derivative Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Serine/threonine Kinase Activator Activity Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Noc4p-Nop14p Complex 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process GDP Catabolic Process Glycerate Kinase Activity Organophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Nucleotide Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission 8-oxo-dGDP Phosphatase Activity Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Cellular Response To Cytokine Stimulus Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Purine Ribonucleotide Biosynthetic Process Nucleus Purine-containing Compound Metabolic Process Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Extracellular Exosome Assembly Nucleoside Phosphate Metabolic Process Ribose Phosphate Biosynthetic Process Response To Cytokine Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking Response To Peptide Nucleobase-containing Small Molecule Metabolic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Voltage-gated Calcium Channel Activity UTP Biosynthetic Process
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