NME7 and OFD1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NME7	OFD1
Gene Name		NME/NM23 family member 7	oral-facial-digital syndrome 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Ciliary Basal Body	Nucleus Centrosome Centriole Cytosol Cilium Microtubule Cytoskeleton Membrane Centriolar Satellite Ciliary Basal Body
	Molecular Function	Nucleoside Diphosphate Kinase Activity ATP Binding Metal Ion Binding	Protein Binding Alpha-tubulin Binding Gamma-tubulin Binding
	Biological Process	Epithelial Cilium Movement Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Determination Of Left/right Symmetry Brain Development Intraciliary Transport Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Left/right Pattern Formation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Embryonic Body Morphogenesis Axoneme Assembly Cilium Morphogenesis Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Mitotic Spindle Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation
Pathways			Organelle biogenesis and maintenance Hedgehog 'off' state Assembly of the primary cilium G2/M Transition Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		D-dimer levels ( 21502573) Venous thromboembolism ( 21980494 22672568)
Protein-Protein Interactions		27 interactors: C1orf189 CCHCR1 CDC42EP2 CEP72 DDX1 FKBP6 FOSL1 GOLGA2 KIAA1598 KRT18 LNX1 MAP4K4 MYOT NAB2 NEFL NT5C2 OFD1 REL SYCE1 TCF4 TCHP TNIP1 TRIM27 TUFT1 YWHAQ ZBTB48 ZNF263	8 interactors: CCSER2 EIF6 GPRASP1 KIAA1377 LUC7L2 NME7 PLK1 RUVBL1
Entrez ID		29922	8481
HPRD ID		11394	02162
Ensembl ID		ENSG00000143156	ENSG00000046651
Uniprot IDs		Q9Y5B8	A6NF31 A8K2T9 E9KL37 O75665
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression Cell Cycle Response To Corticosterone Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Mineralocorticoid Negative Regulation Of Transcription, DNA-templated Intermediate Filament Cytoskeleton Organization Negative Regulation Of Nucleic Acid-templated Transcription Organelle Organization Negative Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Intermediate Filament-based Process Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Golgi To Plasma Membrane CFTR Protein Transport Bone Mineralization Body Morphogenesis Developmental Process Transcription, DNA-templated Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Interleukin-2 Secretion Gamma-tubulin Complex Localization Catenin Import Into Nucleus Vitellogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Cellular Component Assembly Negative Regulation Of Viral Process Biomineral Tissue Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Neurofilament Bundle Assembly Ossification Regulation Of Cellular Component Organization Maintenance Of DNA Repeat Elements RNA Metabolic Process Intracellular Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Regulation Of Cellular Component Size Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Secretion	Microtubule-based Process Microtubule Bundle Formation Organelle Organization Microtubule Cytoskeleton Organization Activation Of APC-Cdc20 Complex Activity G-protein Coupled Receptor Catabolic Process Cellular Macromolecular Complex Assembly Mitotic Cell Cycle Process Polar Body Extrusion After Meiotic Divisions Ribonucleoprotein Complex Assembly Mitotic Cell Cycle Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Cilium Organization Mature Ribosome Assembly Cellular Component Assembly Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis Positive Regulation Of Mitotic Metaphase/anaphase Transition Metaphase/anaphase Transition Of Mitotic Cell Cycle Ribosomal Subunit Export From Nucleus Cell Cycle Process Protein Localization To Chromatin Mitotic Nuclear Division Ribonucleoprotein Complex Biogenesis Cytoskeleton Organization Histone H2A Acetylation Cellular Localization Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Chromosome Segregation
Tagcloud ?		acentrosomal associates cdk5rap2 centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected	1x apparatus consequences depicted digital dimerization disclosed dramatically facial filaments focused golgi half homology implies imported lis1 lish localization localizations motif mutated nucleus oligomerization participate prediction solved tbl1 transducin
Tagcloud (Difference) ?		acentrosomal associates cdk5rap2 centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected	1x apparatus consequences depicted digital dimerization disclosed dramatically facial filaments focused golgi half homology implies imported lis1 lish localization localizations motif mutated nucleus oligomerization participate prediction solved tbl1 transducin
Tagcloud (Intersection) ?