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PACSIN3 and SOS1
Number of citations of the paper that reports this interaction (PMID
14679214
)
56
Data Source:
HPRD
(in vivo, in vitro)
PACSIN3
SOS1
Gene Name
protein kinase C and casein kinase substrate in neurons 3
son of sevenless homolog 1 (Drosophila)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endosome
Plasma Membrane
Membrane
Membrane-bounded Vesicle
Extracellular Vesicular Exosome
Cytosol
Plasma Membrane
Postsynaptic Density
Neuronal Cell Body
Molecular Function
Protein Binding
Phospholipid Binding
Cytoskeletal Protein Binding
Lipid Binding
Calcium Channel Inhibitor Activity
DNA Binding
Ras Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Rho GTPase Activator Activity
Protein Binding
SH3 Domain Binding
Protein Heterodimerization Activity
Biological Process
Endocytosis
Cytoskeleton Organization
Regulation Of Endocytosis
Negative Regulation Of Endocytosis
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of Calcium Ion Transport
Membrane Tubulation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Axon Guidance
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Platelet Activation
Positive Regulation Of Rho GTPase Activity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Signaling by FGFR in disease
SHC-mediated cascade
FCERI mediated MAPK activation
Platelet Aggregation (Plug Formation)
Signaling by EGFRvIII in Cancer
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Regulation of KIT signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Interleukin receptor SHC signaling
Gastrin-CREB signalling pathway via PKC and MAPK
SOS-mediated signalling
SHC-mediated signalling
Signaling by PDGF
DAP12 interactions
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Signaling by ERBB2
Signaling by EGFR
GPCR downstream signaling
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Signalling to RAS
Downstream signal transduction
Signaling by Rho GTPases
Signaling by FGFR mutants
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
Interleukin-2 signaling
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Adaptive Immune System
Signalling to ERKs
Axon guidance
IRS-mediated signalling
IGF1R signaling cascade
Rho GTPase cycle
IRS-related events triggered by IGF1R
EGFR Transactivation by Gastrin
GRB2 events in ERBB2 signaling
Activation of Rac
Downstream signaling of activated FGFR
G alpha (12/13) signalling events
NCAM signaling for neurite out-growth
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
Cell death signalling via NRAGE, NRIF and NADE
SOS-mediated signalling
SHC-mediated signalling
Integrin alphaIIb beta3 signaling
p75 NTR receptor-mediated signalling
Cytokine Signaling in Immune system
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
NGF signalling via TRKA from the plasma membrane
GRB2:SOS provides linkage to MAPK signaling for Integrins
SHC-related events
Tie2 Signaling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell surface interactions at the vascular wall
Signaling by FGFR
SHC1 events in EGFR signaling
FRS2-mediated cascade
IRS-mediated signalling
Signal attenuation
NRAGE signals death through JNK
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Interleukin receptor SHC signaling
FCERI mediated Ca+2 mobilization
Constitutive Signaling by EGFRvIII
Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
ADAM12
ADAM15
ASAP1
ASAP2
DNM1
ITSN1
LGALS13
PACSIN1
PACSIN2
PAK2
RAF1
SOS1
SOS2
SPRY2
SYNJ1
TERF2IP
TRPV4
WASL
52 interactors:
ABI1
ABI3
ANXA2
ATP6V1E1
BIN1
CAV1
CD19
CD2AP
CRK
CRKL
CSF1R
EGFR
EPS8
EPS8L1
EPS8L2
ERBB2
ERBB3
ESR1
FGFR1
FRS2
FYN
GAB1
GRAP
GRB2
HCK
HDLBP
HRAS
ITSN1
ITSN2
LAT2
LCK
MAPK1
MUC1
NCK1
NCK2
PACSIN1
PACSIN3
PIK3R2
PLCG1
PTPN11
PTPN6
RANBP9
RIT2
RRAS
SH3BP5
SH3KBP1
SHC1
SNX18
SNX9
SPTAN1
TNIK
ZAP70
Entrez ID
29763
6654
HPRD ID
05937
01681
Ensembl ID
ENSG00000165912
ENSG00000115904
Uniprot IDs
Q9UKS6
G5E9C8
Q07889
PDB IDs
1AWE
1BKD
1DBH
1NVU
1NVV
1NVW
1NVX
1Q9C
1XD2
1XD4
1XDV
2II0
3KSY
Enriched GO Terms of Interacting Partners
?
Cell Morphogenesis
Cell Projection Morphogenesis
Cell Part Morphogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Anatomical Structure Morphogenesis
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Axon Guidance
Neuron Projection Morphogenesis
Cell Morphogenesis Involved In Differentiation
Neuron Projection Development
Axonogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Neuron Development
Regulation Of Ras Protein Signal Transduction
Anatomical Structure Development
Cell Differentiation
Generation Of Neurons
Regulation Of Small GTPase Mediated Signal Transduction
Neuron Differentiation
Neurogenesis
Developmental Process
Regulation Of Ras GTPase Activity
Synaptic Vesicle Endocytosis
Cell Development
Synaptic Vesicle Recycling
Establishment Of Organelle Localization
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Endocytosis
Organelle Localization
Establishment Of Vesicle Localization
Nervous System Development
Regulation Of GTPase Activity
Vesicle Localization
Neurotrophin TRK Receptor Signaling Pathway
Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Catalytic Activity
Locomotion
Regulation Of Signaling
Neurotrophin Signaling Pathway
Positive Regulation Of Signal Transduction
Cell Communication
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Immune Response-regulating Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Fc-epsilon Receptor Signaling Pathway
Response To Fibroblast Growth Factor
Innate Immune Response
Regulation Of Intracellular Signal Transduction
Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Movement Of Cell Or Subcellular Component
Regulation Of Protein Kinase Activity
Locomotion
Regulation Of Signal Transduction
Regulation Of Immune Response
Regulation Of Catalytic Activity
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Phosphorylation
Response To Growth Factor
Immune System Process
Regulation Of Signaling
Regulation Of Immune System Process
Phosphatidylinositol-mediated Signaling
Cell Surface Receptor Signaling Pathway
Signal Transduction
Signaling
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Phosphorylation
Cell Communication
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phosphorylation
Immune Response
Leukocyte Migration
Positive Regulation Of Protein Modification Process
Endocytosis
Positive Regulation Of Protein Kinase Activity
Defense Response
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Protein Metabolic Process
Tagcloud
?
accordingly
antisense
b9
cascade
cascades
distal
gp130
il
independently
jak
lines
mapk
mediates
mediating
mitogen
mm
myeloma
next
occur
oligonucleotide
proliferated
proliferative
ras
regardless
sense
shc
stat1
stat3
triggered
Tagcloud (Difference)
?
accordingly
antisense
b9
cascade
cascades
distal
gp130
il
independently
jak
lines
mapk
mediates
mediating
mitogen
mm
myeloma
next
occur
oligonucleotide
proliferated
proliferative
ras
regardless
sense
shc
stat1
stat3
triggered
Tagcloud (Intersection)
?