PACSIN3 and KRTAP12-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PACSIN3	KRTAP12-2
Description		protein kinase C and casein kinase substrate in neurons 3	keratin associated protein 12-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Extracellular Exosome	Cytosol Intermediate Filament
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding	Protein Binding
	Biological Process	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		Clathrin-mediated endocytosis	Keratinization
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		24 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 OGT PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL	127 interacting genes: ADAM12 ARID5A ATN1 ATP6V1C2 AVPI1 BCL6B BEX2 CATSPER1 CBLL2 CBX2 CCNL1 CCNL2 CFP CHRD CNNM3 CYSRT1 DGCR6 DHRS1 EFEMP2 ETNK2 FAM27E3 FHL3 FOXD4 FOXD4L1 FOXD4L3 GDF15 GPANK1 GPRIN2 GREM1 HOXA1 HOXB9 HSFX1 HSFX2 HYPK INO80B IQUB KRT34 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP19-2 KRTAP21-2 KRTAP26-1 KRTAP3-2 KRTAP4-2 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1F LCE2A LCE2B LCE4A LCE5A LINC00671 MEOX2 MGAT5B MYOZ1 MYPOP NBPF19 NECTIN2 NOTCH2NLA NPDC1 NR1D2 ODF1 OTX1 PACSIN3 PATZ1 PCSK5 PDE9A PELO PHLDA1 PIH1D2 PLAC8 POLR1C POM121L8P POU4F2 RAD23A RBM39 RBPMS RBX1 RHOXF2 SEMA3B SLC12A4 SLC13A5 SLC15A2 SLC15A3 SPATA3 SPMIP9 SPRED2 SPRY1 SRSF8 TCEA2 TINAGL1 TLE5 TMEM179B TNS2 TRIM42 TRIP13 TSGA10IP TTPA VASN VENTX VGLL3 YIPF3 YY1 ZBTB9 ZDHHC1 ZIM2 ZNF100 ZNF408 ZNF497 ZNF581 ZNF587 ZNF624 ZNF688 ZNF696 ZNF764 ZNF785 ZNHIT1
Entrez ID		29763	353323
HPRD ID		05937	11198
Ensembl ID		ENSG00000165912	ENSG00000221864
Uniprot IDs		Q9UKS6	P59991
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Plasma Membrane Ruffle Membrane Synaptic Vesicle Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Presynaptic Endocytosis Regulation Of Pro-B Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Glutamatergic Synapse Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of T Cell Differentiation Import Into Cell Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane Tubulation Regulation Of Plasma Membrane Organization Cell Projection Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Differentiation Vesicle-mediated Transport In Synapse Schwann Cell Development Endocytosis Protein Kinase Binding Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Protein Localization SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus Establishment Of Organelle Localization Cytoplasmic Vesicle Vesicle Budding From Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Clathrin Coat Assembly Involved In Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Regulation Of Lymphocyte Activation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway B Cell Homeostasis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation	Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Tissue Development Regulation Of Nucleobase-containing Compound Metabolic Process Peptidoglycan Transport Identical Protein Binding Peptide:proton Symporter Activity Dipeptide Transmembrane Transporter Activity Negative Regulation Of Lens Fiber Cell Differentiation Dipeptide Transmembrane Transport Dipeptide Import Across Plasma Membrane Dipeptide Transport
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