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PACSIN3 and SOS2
Number of citations of the paper that reports this interaction (PMID
14679214
)
56
Data Source:
HPRD
(in vitro, in vivo)
PACSIN3
SOS2
Gene Name
protein kinase C and casein kinase substrate in neurons 3
son of sevenless homolog 2 (Drosophila)
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endosome
Plasma Membrane
Membrane
Membrane-bounded Vesicle
Extracellular Vesicular Exosome
Cytosol
Molecular Function
Protein Binding
Phospholipid Binding
Cytoskeletal Protein Binding
Lipid Binding
Calcium Channel Inhibitor Activity
DNA Binding
Rho Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Heterodimerization Activity
Biological Process
Endocytosis
Cytoskeleton Organization
Regulation Of Endocytosis
Negative Regulation Of Endocytosis
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of Calcium Ion Transport
Membrane Tubulation
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Apoptotic Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
Rho GTPase cycle
GPCR downstream signaling
Activation of Rac
NRAGE signals death through JNK
Signaling by Rho GTPases
G alpha (12/13) signalling events
Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
ADAM12
ADAM15
ASAP1
ASAP2
DNM1
ITSN1
LGALS13
PACSIN1
PACSIN2
PAK2
RAF1
SOS1
SOS2
SPRY2
SYNJ1
TERF2IP
TRPV4
WASL
16 interactors:
ABI1
ABL1
BIN1
CD2AP
CRKL
EGFR
GRAP2
GRB2
HRAS
ITSN2
PACSIN3
PLCG1
SH3D19
SHC1
SNX18
SNX9
Entrez ID
29763
6655
HPRD ID
05937
03149
Ensembl ID
ENSG00000165912
ENSG00000100485
Uniprot IDs
Q9UKS6
B7ZKT6
Q07890
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cell Morphogenesis
Cell Projection Morphogenesis
Cell Part Morphogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Anatomical Structure Morphogenesis
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Axon Guidance
Neuron Projection Morphogenesis
Cell Morphogenesis Involved In Differentiation
Neuron Projection Development
Axonogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Neuron Development
Regulation Of Ras Protein Signal Transduction
Anatomical Structure Development
Cell Differentiation
Generation Of Neurons
Regulation Of Small GTPase Mediated Signal Transduction
Neuron Differentiation
Neurogenesis
Developmental Process
Regulation Of Ras GTPase Activity
Synaptic Vesicle Endocytosis
Cell Development
Synaptic Vesicle Recycling
Establishment Of Organelle Localization
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Endocytosis
Organelle Localization
Establishment Of Vesicle Localization
Nervous System Development
Regulation Of GTPase Activity
Vesicle Localization
Neurotrophin TRK Receptor Signaling Pathway
Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Catalytic Activity
Locomotion
Regulation Of Signaling
Neurotrophin Signaling Pathway
Positive Regulation Of Signal Transduction
Cell Communication
Cell Surface Receptor Signaling Pathway
Endocytosis
Fc Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Vesicle-mediated Transport
Positive Regulation Of Metabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cellular Protein Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of Kinase Activity
Innate Immune Response
Positive Regulation Of Signal Transduction
Positive Regulation Of Phosphorylation
Regulation Of Catalytic Activity
Regulation Of Immune Response
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Positive Regulation Of Cellular Metabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Activation Of MAPKK Activity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Hydrolase Activity
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Ras Protein Signal Transduction
Positive Regulation Of MAPK Cascade
Lipid Tube Assembly
Cell Migration
Immune Response
Regulation Of Immune System Process
Activation Of Protein Kinase Activity
Defense Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud
?
arnt
bio
biogrid
bmpr1b
crebl
dijkstra
ecm
etc
greedy
hsc
hscs
integrative
iterative
kegg
map2k1
nf1
pik3r3
ppp2r1a
prkca
searching
smad2
stellate
targetome
tfs
tranfac
transcriptome
transcriptomic
uncovered
underlie
Tagcloud (Difference)
?
arnt
bio
biogrid
bmpr1b
crebl
dijkstra
ecm
etc
greedy
hsc
hscs
integrative
iterative
kegg
map2k1
nf1
pik3r3
ppp2r1a
prkca
searching
smad2
stellate
targetome
tfs
tranfac
transcriptome
transcriptomic
uncovered
underlie
Tagcloud (Intersection)
?