PACSIN3 and ASAP1

Number of citations of the paper that reports this interaction (PubMedID 15719014)
36

Data Source:
HPRD (two hybrid)

		PACSIN3	ASAP1
Description		protein kinase C and casein kinase substrate in neurons 3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Extracellular Exosome	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Trans-Golgi Network Membrane Centriolar Satellite
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding
	Biological Process	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation	Cell Projection Organization Cilium Assembly Protein Localization To Cilium Positive Regulation Of Membrane Tubulation
Pathways		Clathrin-mediated endocytosis	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)	Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels in HIV infection ( 33109212) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Sleep duration (> 10 hours) ( 33075057) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		24 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 OGT PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL	15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC
Entrez ID		29763	50807
HPRD ID		05937	05809
Ensembl ID		ENSG00000165912	ENSG00000153317
Uniprot IDs		Q9UKS6	A0A0A0MRE5 Q9ULH1
PDB IDs			2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Plasma Membrane Ruffle Membrane Synaptic Vesicle Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Presynaptic Endocytosis Regulation Of Pro-B Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Glutamatergic Synapse Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of T Cell Differentiation Import Into Cell Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane Tubulation Regulation Of Plasma Membrane Organization Cell Projection Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Differentiation Vesicle-mediated Transport In Synapse Schwann Cell Development Endocytosis Protein Kinase Binding Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Protein Localization SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus Establishment Of Organelle Localization Cytoplasmic Vesicle Vesicle Budding From Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Clathrin Coat Assembly Involved In Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Regulation Of Lymphocyte Activation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway B Cell Homeostasis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation	Focal Adhesion Signal Complex Assembly Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Morphogenesis Endocytosis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Actin Filament Organization Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Vesicle-mediated Transport Plasma Membrane Positive Regulation Of Organelle Organization Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Import Into Cell Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Immune Effector Process Anchoring Junction Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cytoplasm Positive Regulation Of Cellular Component Organization Integrin-mediated Signaling Pathway Protein Localization To Cleavage Furrow SH3 Domain Binding Cellular Response To Fluid Shear Stress Protein Autophosphorylation Fc-gamma Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity
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