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PACSIN3 and PAK2
Number of citations of the paper that reports this interaction (PMID
16374509
)
26
Data Source:
HPRD
(in vitro)
PACSIN3
PAK2
Gene Name
protein kinase C and casein kinase substrate in neurons 3
p21 protein (Cdc42/Rac)-activated kinase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endosome
Plasma Membrane
Membrane
Membrane-bounded Vesicle
Extracellular Vesicular Exosome
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Phospholipid Binding
Cytoskeletal Protein Binding
Lipid Binding
Calcium Channel Inhibitor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Identical Protein Binding
Biological Process
Endocytosis
Cytoskeleton Organization
Regulation Of Endocytosis
Negative Regulation Of Endocytosis
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of Calcium Ion Transport
Membrane Tubulation
Mitotic Cell Cycle
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Signal Transduction
Axon Guidance
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Signal Transduction By Phosphorylation
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Growth
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Costimulation by the CD28 family
Axon guidance
HIV Infection
FCERI mediated MAPK activation
VEGFA-VEGFR2 Pathway
Nef and signal transduction
Ephrin signaling
Activation of Rac
VEGFR2 mediated vascular permeability
Programmed Cell Death
EPH-Ephrin signaling
Innate Immune System
Generation of second messenger molecules
Semaphorin interactions
Apoptotic execution phase
CD28 co-stimulation
Regulation of activated PAK-2p34 by proteasome mediated degradation
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
CD28 dependent Vav1 pathway
Stimulation of the cell death response by PAK-2p34
TCR signaling
Signaling by VEGF
Sema3A PAK dependent Axon repulsion
Fc epsilon receptor (FCERI) signaling
Signaling by Robo receptor
Regulation of Apoptosis
Adaptive Immune System
Drugs
Diseases
GWAS
Total ventricular volume (
21116278
)
Protein-Protein Interactions
18 interactors:
ADAM12
ADAM15
ASAP1
ASAP2
DNM1
ITSN1
LGALS13
PACSIN1
PACSIN2
PAK2
RAF1
SOS1
SOS2
SPRY2
SYNJ1
TERF2IP
TRPV4
WASL
51 interactors:
ABI1
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
DOCK2
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
HCK
HIST1H4F
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
PACSIN3
RAC1
RAC2
RAF1
RHOJ
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
29763
5062
HPRD ID
05937
05428
Ensembl ID
ENSG00000165912
ENSG00000180370
Uniprot IDs
Q9UKS6
A8K5M4
Q13177
PDB IDs
3PCS
Enriched GO Terms of Interacting Partners
?
Cell Morphogenesis
Cell Projection Morphogenesis
Cell Part Morphogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Anatomical Structure Morphogenesis
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Axon Guidance
Neuron Projection Morphogenesis
Cell Morphogenesis Involved In Differentiation
Neuron Projection Development
Axonogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Neuron Development
Regulation Of Ras Protein Signal Transduction
Anatomical Structure Development
Cell Differentiation
Generation Of Neurons
Regulation Of Small GTPase Mediated Signal Transduction
Neuron Differentiation
Neurogenesis
Developmental Process
Regulation Of Ras GTPase Activity
Synaptic Vesicle Endocytosis
Cell Development
Synaptic Vesicle Recycling
Establishment Of Organelle Localization
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Endocytosis
Organelle Localization
Establishment Of Vesicle Localization
Nervous System Development
Regulation Of GTPase Activity
Vesicle Localization
Neurotrophin TRK Receptor Signaling Pathway
Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Catalytic Activity
Locomotion
Regulation Of Signaling
Neurotrophin Signaling Pathway
Positive Regulation Of Signal Transduction
Cell Communication
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Endocytosis
Movement Of Cell Or Subcellular Component
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Axon Guidance
Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Locomotion
Cytoskeleton Organization
Chemotaxis
Phagocytosis
Axonogenesis
Neurotrophin TRK Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Immune Response-regulating Signaling Pathway
ERBB Signaling Pathway
Axon Development
Cellular Response To Peptide Hormone Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Cellular Response To Peptide
Cell Projection Organization
Actin Filament-based Process
Neuron Projection Morphogenesis
Signal Transduction
Signaling
Response To Peptide Hormone
Peptidyl-tyrosine Autophosphorylation
Cell Communication
Innate Immune Response
Cellular Response To Organonitrogen Compound
Cell Development
Cellular Response To Growth Factor Stimulus
Apoptotic Process
Response To Peptide
Intracellular Signal Transduction
Actin Cytoskeleton Organization
Cell Projection Morphogenesis
Regulation Of Immune System Process
Cellular Response To Organic Substance
Response To Growth Factor
Cell Part Morphogenesis
Programmed Cell Death
Tagcloud
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pakl
phenomena
probed
proliferate
proto
raf1
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Difference)
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pakl
phenomena
probed
proliferate
proto
raf1
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Intersection)
?