PACSIN3 and LGALS13

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PACSIN3	LGALS13
Description		protein kinase C and casein kinase substrate in neurons 3	galectin 13
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Body
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding	Phosphatidylcholine Lysophospholipase Activity Protein Binding Carbohydrate Binding
	Biological Process	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation	Phospholipid Metabolic Process Apoptotic Process
Pathways		Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)	Lead levels ( 26025379)
Interacting Genes		24 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 OGT PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL	10 interacting genes: ACTB ACTG1 ANXA2 CREB5 HOXA1 NUFIP2 OTX1 PACSIN3 PHLDA1 POU4F2
Entrez ID		29763	29124
HPRD ID		05937	16375
Ensembl ID		ENSG00000165912	ENSG00000105198
Uniprot IDs		Q9UKS6	Q9UHV8
PDB IDs			5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Plasma Membrane Ruffle Membrane Synaptic Vesicle Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Presynaptic Endocytosis Regulation Of Pro-B Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Glutamatergic Synapse Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of T Cell Differentiation Import Into Cell Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane Tubulation Regulation Of Plasma Membrane Organization Cell Projection Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Differentiation Vesicle-mediated Transport In Synapse Schwann Cell Development Endocytosis Protein Kinase Binding Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Protein Localization SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus Establishment Of Organelle Localization Cytoplasmic Vesicle Vesicle Budding From Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Clathrin Coat Assembly Involved In Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Regulation Of Lymphocyte Activation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway B Cell Homeostasis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation	Positive Regulation Of Macromolecule Metabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Regulation Of Endocytosis DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Axonogenesis Regulation Of Synaptic Vesicle Endocytosis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Regulation Of Transcription By RNA Polymerase II Regulation Of Vesicle-mediated Transport DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Sequence-specific Double-stranded DNA Binding Platelet Aggregation Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Formation Diencephalon Morphogenesis Homotypic Cell-cell Adhesion Negative Regulation Of Endocytosis Cytoskeletal Protein Binding Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Protein Localization To Cell Junction Regulation Of RNA Biosynthetic Process Regulation Of Norepinephrine Uptake Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
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