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USP25 and GAPDH
Number of citations of the paper that reports this interaction (PubMedID
16501887
)
0
Data Source:
BioGRID
(two hybrid)
USP25
GAPDH
Description
ubiquitin specific peptidase 25
glyceraldehyde-3-phosphate dehydrogenase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Cytoskeleton
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Nuclear Membrane
Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
GAIT Complex
Ribonucleoprotein Complex
Molecular Function
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin-like Protein Peptidase Activity
Ubiquitin Protein Ligase Binding
SUMO Binding
Ubiquitin Binding
ATPase Binding
Deubiquitinase Activity
Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity
Protein Binding
Microtubule Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor
Transferase Activity
Aspartic-type Endopeptidase Inhibitor Activity
Peptidyl-cysteine S-nitrosylase Activity
Identical Protein Binding
NADP Binding
NAD Binding
Disordered Domain Specific Binding
Biological Process
Proteolysis
Protein Deubiquitination
Regulation Of Protein Stability
Cellular Response To Oxidative Stress
Protein Modification Process
Interleukin-17A-mediated Signaling Pathway
Protein K63-linked Deubiquitination
Protein K48-linked Ubiquitination
Protein K48-linked Deubiquitination
Negative Regulation Of Response To Oxidative Stress
Negative Regulation Of Interleukin-17-mediated Signaling Pathway
Negative Regulation Of ERAD Pathway
Microtubule Cytoskeleton Organization
Positive Regulation Of Cytokine Production
Immune System Process
Glucose Metabolic Process
Glycolytic Process
Regulation Of Translation
Apoptotic Process
Negative Regulation Of Endopeptidase Activity
Regulation Of Macroautophagy
Negative Regulation Of Translation
Killing Of Cells Of Another Organism
Positive Regulation Of Type I Interferon Production
Peptidyl-cysteine S-trans-nitrosylation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Stabilization
Defense Response To Fungus
Neuron Apoptotic Process
Killing By Host Of Symbiont Cells
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cellular Response To Type II Interferon
Pathways
Ub-specific processing proteases
Glycolysis
Gluconeogenesis
Drugs
NADH
Adenosine-5-Diphosphoribose
Thionicotinamide-Adenine-Dinucleotide
4-(2-Aminoethyl)Benzenesulfonyl Fluoride
Xanthinol
Copper
Artenimol
Diseases
GWAS
Crohn's disease (
25489960
)
Metabolite levels (
23823483
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Panic disorder (
19165232
)
Parkinson's disease (
21738487
)
QRS complex (12-leadsum) (
27659466
)
Serum alkaline phosphatase levels (
33547301
)
Severe autoimmune type 2 diabetes (
34737425
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Blood protein levels (
30072576
)
Interacting Genes
37 interacting genes:
ACTA1
ARMC8
CDC73
CNTN1
EIF4A3
FBXL17
FLNC
GAPDH
GDI1
MAGEB4
MAVS
MID2
MT2A
NAP1L3
PAX6
PUS10
RAD23A
RAD23B
RPS10-NUDT3
RSL1D1
SENP1
SKIL
SNRNP70
SUMO1
SUMO2
SUMO3
SYK
TMEM43
TNKS
TNKS2
TUBB
UBC
UBE2I
VPS45
YARS1
ZNF426
ZNF841
92 interacting genes:
ACD
ACTB
ACTC1
ANXA1
ANXA7
APP
AR
ARL15
ATN1
ATXN1
BID
BPGM
BTBD2
CAMK1
CAMK2B
CAMK4
CDKN1A
CDKN2A
CEBPA
CHP1
DUX4
DYNLL1
EGFR
ERBB2
FBXO7
FKBP6
FOXP1
GADD45A
GAS7
GOT2
GRIA2
GRM1
HES1
HNF4G
HSPB2
HTT
ITGB5
KARS1
KAT5
KCNE3
LAMA4
LAMTOR5
LIG4
LINC01554
MAPK1
MTNR1A
MYOC
NFYC
NR1H4
NUFIP2
OGT
OSMR
OSTF1
PAFAH1B3
PCDHA4
PCNA
PDIA2
PGK1
PLD2
POT1
POU2F2
PPM1E
PRDX1
PRKCI
PRPF40A
PSEN1
PSMD11
PTPRF
RAB2A
RBM5
RPA2
RXFP4
S100A6
SERPINB9
SHANK3
SIAH1
SIRT1
SLC2A1
SLC2A4
SMARCA2
SMN1
SUMO4
TERF1
TINF2
TK1
TPPP
TSC2
TXNIP
USP25
WEE2-AS1
YWHAE
YWHAQ
Entrez ID
29761
2597
HPRD ID
05296
00713
Ensembl ID
ENSG00000155313
ENSG00000111640
Uniprot IDs
Q9UHP3
P04406
V9HVZ4
PDB IDs
2MUX
5GP7
5O71
6H4J
6H4K
6HEL
6HEM
1U8F
1ZNQ
3GPD
4WNC
4WNI
6ADE
6IQ6
6M61
6YND
6YNE
6YNF
6YNH
8DNS
8G12
8G13
8G14
8G15
8G16
8G17
8P5F
Enriched GO Terms of Interacting Partners
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Presynaptic Cytosol
Protein Tag Activity
Protein Sumoylation
Postsynaptic Cytosol
Nucleus
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
PML Body
Protein Poly-ADP-ribosylation
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Modification Process
Ubiquitin-like Protein Ligase Binding
Macromolecule Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Small Protein Activating Enzyme Binding
Positive Regulation Of Telomere Capping
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Glutamatergic Synapse
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Protein Localization To Chromosome, Telomeric Region
Protein Auto-ADP-ribosylation
NAD+-protein-glutamate ADP-ribosyltransferase Activity
NAD+-protein-aspartate ADP-ribosyltransferase Activity
Regulation Of Telomere Capping
Protein Localization To Organelle
Cytoplasm
Positive Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
Cytosol
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Proteasome Binding
Negative Regulation Of DNA Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-specific Protease Binding
Cellular Response To Cadmium Ion
SUMO Transferase Activity
Transcription Factor Binding
Nuclear Pore
NAD+-protein Mono-ADP-ribosyltransferase Activity
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Pericentriolar Material
Positive Regulation Of Telomere Maintenance Via Telomerase
Response To Cytokine
Developmental Process
Cellular Developmental Process
Nucleus
Cell Differentiation
Regulation Of Programmed Cell Death
Regulation Of Phosphorus Metabolic Process
Shelterin Complex
Regulation Of Cellular Component Organization
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Identical Protein Binding
Nuclear Telomere Cap Complex
Protein-containing Complex
Regulation Of Cellular Localization
Cellular Response To Stress
Regulation Of Cellular Response To Stress
Regulation Of Multicellular Organismal Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Protein Localization
Regulation Of DNA Metabolic Process
Telomeric DNA Binding
Telomere Capping
Regulation Of Phosphorylation
Nucleoplasm
Regulation Of Developmental Process
Negative Regulation Of DNA Biosynthetic Process
DNA Biosynthetic Process
Telomere Assembly
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Regulation Of Chromosome Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Biosynthetic Process
Cytosol
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Signaling
Positive Regulation Of Chromosome Organization
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Development
Positive Regulation Of Cellular Component Organization
System Development
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